Skip to main content
SpringerLink
Log in

Comparative in vitro activity of A-56268 (TE-031), a new macrolide antibiotic

  • Notes
  • New Antimicrobial Agents
  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

The in vitro activity of A-56268 (TE-031) was determined by either standard agar dilution or macrobroth tube dilution and comapred with erythromycin and other antimicrobial agents against 329 clinical aerobic and anaerobic bacterial isolates. A-56268 showed good to excellent in vitro activity against methicillin-sensitiveStaphylococcus aureus,Neisseria meningitidis, and most anaerobes tested with the exception ofBacteroides fragilis isolates. A-56268 had relatively poor activity against coagulase-negative staphylococci and methicillin-resistantStaphylococcus aureus. Except forHaemo philus spp., the activity of A-56268 was similar to or more potent than erythromycin against all other isolates tested. A-56268 did not have significant bactericidal activity against any of the isolates examined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Peaxson, R. D., Steigbigel, R. T., Davis, H. T., Chapman, S. W.: Method for reliable determination of minimal lethal antibiotic concentrations. Antimicrobial Agents and Chemotherapy 1980, 18: 699–708.

    PubMed  Google Scholar 

  2. Washington, J. A., II, Sutter, V. L.: Dilution susceptibility test: agar and macro-broth dilution procedures. In: Lennette, E. H., Balows, A., Hausier, W. J., Traunt, J. P. (ed.): Manual of clinical microbiology. American Society for Microbiology, Washington, D. C. 1980, p. 453–458.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Microbiology-Immunology Laboratories, North Carolina Memorial Hospital, 27514, Chapel Hill, North Carolina, USA

    R. L. Hodinka, K. Jack-Wait & P. H. Gilligan

  2. Departments of Microbiology-Immunology and Pathology, School of Medicine, University of North Carolina, 27514, Chapel Hill, North Carolina, USA

    P. H. Gilligan

Authors
  1. R. L. Hodinka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Jack-Wait
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. H. Gilligan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hodinka, R.L., Jack-Wait, K. & Gilligan, P.H. Comparative in vitro activity of A-56268 (TE-031), a new macrolide antibiotic. Eur. J, Clin. Microbiol. 6, 103–108 (1987). https://doi.org/10.1007/BF02097212

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02097212

Keywords

Search

Navigation