Abstract
Two patients with relapsing Clostridium difficile diarrhoea following metronidazole and vancomycin therapy were colonised with a non-toxigenic avirulent Clostridium difficile strain given orally in three doses. Both patients appeared to respond without sideeffects. Oral bacteriotherapy with a defined nontoxigenic strain of Clostridium difficile would appear to represent an acceptable, alternative and novel way to treat hospitalised patients who relapse with Clostridium difficile diarrhoea after specific antibiotic therapy.
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Seal, D., Borriello, S.P., Barclay, F. et al. Treatment of relapsingClostridium difficile diarrhoea by administration of a non-toxigenic strain. Eur. J, Clin. Microbiol. 6, 51–53 (1987). https://doi.org/10.1007/BF02097191
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DOI: https://doi.org/10.1007/BF02097191