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Esophageal dysmotility in children breast-fed by mothers with silicone breast implants

Long-term follow-up and response to treatment

  • Esophageal, Gastric, And Duodenal Disorders
  • Published:
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Abstract

Our aims were to determine the long-term clinical and manometric follow-up of 11 children with previously documented esophageal dysmotility, who had been breast-fed by mothers with silicone breast implants, their response to prokinetic agents, and to analyze changes in macrophage activation. Seven of 11 children had subjective clinical improvement. Weight/height ratios remained the same or improved in 9/11. Biopsies at follow-up endoscopy were either normal or demonstrated mild esophagitis in 8/10. LES and UES pressures and percent propagation were not significantly different at follow-up, while wave amplitude significantly increased. Following intravenous metoclopramide, LES pressure, percent propagation, and wave amplitude significantly increased while UES pressure was unchanged. Urinary neopterin significantly decreased at follow-up, while urinary nitrates were unchanged. Esophageal dysmotility is chronic in this group of children, suggesting persistent autonomic nervous system dysfunction. Prokinetic agents may be useful in long-term management. The decreasing urinary neopterin levels suggest that, ultimately, there may be improvement in esophageal motility.

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Authors and Affiliations

  1. From the Divisions of Gastroenterology and Nutrition, and Nephrology, Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, New York

    Jeremiah J. Levine MD, Howard Trachtman MD, David M. Gold MD & Michael J. Pettei MD, PhD

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  1. Jeremiah J. Levine MD
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  2. Howard Trachtman MD
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  3. David M. Gold MD
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  4. Michael J. Pettei MD, PhD
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Levine, J.J., Trachtman, H., Gold, D.M. et al. Esophageal dysmotility in children breast-fed by mothers with silicone breast implants. Digest Dis Sci 41, 1600–1603 (1996). https://doi.org/10.1007/BF02087907

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  • DOI: https://doi.org/10.1007/BF02087907

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