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Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers

  • Esophageal, Gastric, And Duodenal Disorders
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Abstract

Our objective was to investigate the putative role of epidermal growth factor (EGF) in esophagitis pathogenesis in both nondrinkers and chronic alcoholics. We studied the EGF serum level, the EGF salivary concentration, and the esophageal EGF receptor expression in different groups of patients with esophagitis: nondrinkers with typical symptoms of gastroesophageal reflux (N=12) and chronic alcoholics (N=12), and in controls: chronic alcoholics without esophagitis (N=16) and healthy nondrinkers (N=12). All patients had an endoscopy with esophageal biopsies, 24-hr esophageal pH-metry, and esophageal manometry. EGF serum levels and EGF salivary concentrations were determined by radioimmunoassay. EGF receptor expression was determined by immunohistochemistry. Both the EGF serum level and the EGF salivary concentration remained constant, 328±21 pg/ml and 305±48 pg/ml, respectively, regardless of alcohol intake and the presence or absence of esophagitis. In addition, the presence of esophagitis did not affect the EGF receptor expression. These results suggest that seric and salivary EGF is not involved in the pathogenesis of reflux esophagitis in nondrinkers and in chronic alcoholics.

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Authors and Affiliations

  1. From the Department of Hepato-gastroenterology, Department of Biochemistry, and Department of Pathology, Avicenne Hospital, 125 Route de Stalingrad, 93000, Bobigny, France

    Robert Benamouzig MD, Françoise Ferrière MD, Catherine Guettier MD, Jacques Amouroux MD, Thierry Coste MD & Jacques Rautureau MD

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  1. Robert Benamouzig MD
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  2. Françoise Ferrière MD
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  3. Catherine Guettier MD
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  4. Jacques Amouroux MD
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  5. Thierry Coste MD
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  6. Jacques Rautureau MD
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Benamouzig, R., Ferrière, F., Guettier, C. et al. Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers. Digest Dis Sci 41, 1595–1599 (1996). https://doi.org/10.1007/BF02087906

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  • DOI: https://doi.org/10.1007/BF02087906

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