Skip to main content
SpringerLink
Log in

Thiazides in the prophylactic treatment of recurrent idiopathic kidney stones

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

In a double-blind prospective clinical study patients with at least two verified episodes of urolithiasis, but stone-free at the time of inclusion in the study, were subjected to prophylactic treatment with either bendroflumethiazide (2.5 mg)+573 mg potassium chloride 3 times a day, or placebo. The material included a total of 22 patients, all males, aged 20–49 years. We found a clear tendency to reduced stone formation in the group treated with the active drug (P<0.1). Calcium excretion was reduced by 25–50% in 7 of 12 patients treated with thiazide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yendt, E. R., Guay, G. F., Garcia, D. A.: The use of thiazides in the prevention of renal calculi.Can. Med. Assoc. J., 102, 614 (1970).

    PubMed  Google Scholar 

  2. Lamberg, B. A., Kuhlbäck, B.: Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in urine.Scand. J. Clin. Invest., 11, 351 (1959).

    PubMed  Google Scholar 

  3. Yendt, E. R., Cagne, R. J. A., Cohanin, M.: The effects of thiazides in idiopathic hypercalciuria.Trans. Am. Clin. Climatol. Assoc., 77, 96 (1965).

    PubMed  Google Scholar 

  4. Jørgensen, F. S.: Effect of thiazide diuretics upon calcium metabolism.Dan. Med. Bull. 23, 223 (1976).

    PubMed  Google Scholar 

  5. Ljunghall, S., Christensson, T., Wengle, B.: Prevalence and incidence of renal disease in a health screening programme.Scand. J. Urol. Nephrol., 41, Suppl. 41, 39 (1977).

    Google Scholar 

  6. Backmann, U., Danielsson, B. G., Johansson, G., Ljunghall, S., Wikström, B.: Effects of therapy with bendroflumethiazide in patients with recurrent renal calcium stones.Br. J. Urol., 51, 175 (1979).

    PubMed  Google Scholar 

  7. Coe, F. I.: Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorders.Ann. Intern. Med., 97, 404 (1977).

    Google Scholar 

  8. Yendt, E. R., Cohanin, M.: Prevention of calcium stones with thiazides.Kidney Int., 13, 397 (1978).

    PubMed  Google Scholar 

  9. Brocks, P., Dahl, C., Transbøl, I., Wolf, H.: Forebygger tiazider recidiverende idiopatiske nyresten?Ugeskr. Laeger., 144, 1669 (1982).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology T, Copenhagen Country Hospital, Glostrup, Denmark

    J. T. Mortensen, A. Schultz & A. H. Østergaard

Authors
  1. J. T. Mortensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Schultz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. H. Østergaard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mortensen, J.T., Schultz, A. & Østergaard, A.H. Thiazides in the prophylactic treatment of recurrent idiopathic kidney stones. International Urology and Nephrology 18, 265–269 (1986). https://doi.org/10.1007/BF02082712

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02082712

Keywords

Search

Navigation