Abstract
A latex agglutination test which detects candida antigen in patients with disseminated infection was used to screen 328 patients. Of these patients 100 had renal failure but no signs or symptoms of candida infection, and 100 had high rheumatoid factor titers but also no signs or symptoms of candida infection. The remaining 128 patients were considered at high risk of developing systemic candida infection. Sequential titers were also determined in a number of these patients. The incidence of candida antigen titers ⩾ 1∶4 in the low-risk population was 3% as compared to 53% in the high-risk group. None of the patients with positive rheumatoid factor titers had candida antigen titers ⩾ 1∶2, however 13% had nonspecific agglutination at titers > 1∶2. The incidence of nonspecific agglutination increased with increasing rheumatoid factor titers. In general the candida antigen titers correlated well with clinical findings and with the course of infection in those patients in whom sequential candida antigen titers were determined. This latex test thus appears to be a useful adjunct procedure for the diagnosis of serious candida infections.
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Gentry, L. O., Wilkinson, I. D., Lea, A. S., Price, M. F.: Latex agglutination test for detection of Candida antigen in patients with disseminated disease. European Journal of Clinical Microbiology 1983, 2: 122–128.
Burnie, J. P., Williams, J. D.: Evaluation of the Ramco latex agglutination test in the early diagnosis of systemic candidiasis. European Journal Clinical Microbiology 1985, 4: 98–101.
Edwards, J. E.:Candida species. In: Mandell, C. L., Douglas, R. C., Bennett, J. E. (ed.): Principles and practice of infectious diseases. John Wiley, New York, 1979, p. 1981–2002.
Hart, P. D., Russell, E., Remington, J. S.: The compromised host and infection. II: Deep fungal infection. Journal Infectious Disease 1969, 120: 169–191.
Bodey, G. P., Fainstein, V.: Systemic candidiasis. In: Bodey, G. P., Fainstein, V. (ed.): Candidiasis. Raven Press, New York, 1985, p. 145–148.
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Price, M.F., Gentry, L.O. Incidence and significance of candida antigen in low-risk and high-risk patient populations. Eur. J, Clin. Microbiol. 5, 416–419 (1986). https://doi.org/10.1007/BF02075697
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DOI: https://doi.org/10.1007/BF02075697