Abstract
One hundred and twenty-three female patients suffering from uncomplicated urogenital gonorrhoea were treated in a double blind randomised trial with either 200 mg enoxacin (one capsule of 200 mg, one of placebo) or 400 mg enoxacin (two capsules of 200 mg). The cure rate in the 46 evaluable patients in the 400 mg group was 100 %, and in the 40 evaluable patients in the 200 mg group 98.7 %. Minor side effects such as nausea, headache and skin rash occurred in three of 109 evaluable patients (2.8 %). The minimum inhibitory concentration of enoxacin for the Neisseria gonorrhoeae strains isolated varied between 0.03 and 0.12 mcg/ml. Enoxacin would seem to be a very effective drug in the treatment of uncomplicated urogenital gonorrhoea in female patients.
Similar content being viewed by others
References
van Klingeren, B., van Wijngaarden, J. L., Dessens-Kroon, M., van Embden, J. D. A.: Penicillinase-producing gonococci in The Netherlands in 1981. Journal of Antimicrobial Chemotherapy 1983, 11: 15–20.
Nayyar, K. C., Noble, R. C., Michel, M. F., Stolz, E.: Gonorrhoea in Rotterdam caused by penicillinase-producing gonococci. British Journal of Venereal Diseases 1980, 56: 244–248.
Nayyar, K. C., Michel, M. F., Stolz, E.: Antibiotic sensitivity of gonococci isolated in Rotterdam and results of treatment with cefuroxime. British Journal of Venereal Diseases 1980, 56: 249–251.
Reeves, D. S., Baywater, J. J., Holt, H. A.: The activity of enoxacin against clinical bacterial isolates in comparison with that of five other agents, and factors affecting that activity. Journal of Antimicrobial Chemotherapy 1984, 14: 7–17.
Notowicz, A., Stolz, E., van Klingeren, B.: A double blind study comparing two dosages of enoxacin for the treatment of uncomplicated urogenital gonorrhoea. Journal of Antimicrobial Chemotherapy 1984, 14: 91–94.
Chin, M. X., Neu, H. C.: In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, newβ-lactams, aminoglycosides and trimethoprim. Antimicrobial Agents and Chemotherapy 1983, 24: 754–763.
Wolf, R., Eberl, R., Dunky, A., Mertz, N., Chang, T., Goulet, J. R., Latts, J.: The clinical pharmacokinetics and tolerance of enoxacin in healthy volunteers. Journal of Antimicrobial Chemotherapy 1984, 14: 63–69.
Aardoom, H. A., de Hoop, D., Iserief, C. D. A., Michel, M. F., Stolz, E.: Detection ofNeisseria gonorrhoeae antigen by a solid-phase enzyme immunoassay. British Journal of Venereal Diseases 1981, 58: 359–362.
Stolz, E., Zwart, H. G. F., Michel, M. F.: Sensitivity to ampicillin, penicillin and tetracycline of gonococci in Rotterdam. British Journal of Venereal Diseases 1974, 50: 202–204.
Ansink-Schipper, M. C., Huikeshoven, M. H., Woudstra, R. K., van Klingeren, B., de Koning, G. A. J., Tio, D., Jansen-Schoonhoven, F., Goutinho, R.: Epidemiology of penicillinase-producingNeisseria gonorrhoeae in Amsterdam. Analysis by auxanographic typing and plasmid characterization. British Journal of Venereal Diseases 1984, 60: 23–38.
Schalla, W. O., Whittington, W. L., Rice, R. J., Larsen, S. A.: Epidemiology characterization ofNeisseria gonorrhoeae by lectins. Journal of Clinical Microbiology 1985, 22: 379–382.
Knapp, J. S., Tam, M. R., Nowinski, R. C., Holmes, K. K., Sandström, E. G.: Serological classification ofNeisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I. Journal of Infectious Diseases 1984, 1: 44–47.
Tegelberg-Stassen, M. J., van der Hoek, J. C., Mooi, L., Wagenvoort, J. H., van Joost, T., Michel, M. F., Stolz, E.: Treatment of uncomplicated gonococcal urethritis in men with two dosages of ciprofloxacin. European Journal of Clinical Microbiology 1986, 5: 244–246.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tegelberg-Stassen, M.J., van der Willigen, A.H., van der Hoek, J.C. et al. Treatment of uncomplicated urogenital gonorrhoea in women with a single oral dose of enoxacin. Eur. J, Clin. Microbiol. 5, 395–398 (1986). https://doi.org/10.1007/BF02075693
Issue Date:
DOI: https://doi.org/10.1007/BF02075693