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Pancreatic growth and function following surgical treatment of nesidioblastosis in infancy

  • Endocrinology
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Abstract

Pancreatic exocrine and endocrine function was assessed in four patients 4–31 months after 88%–95% pancreatectomy. Postoperative exocrine and endocrine function was not seriously impaired. Extensive pancreatic regrowth occurred. The amount of regenerated pancreatic tissue, estimated by sonographic measurement of the sectional area, was not significantly different from that of healthy controls. Pancreatic endocrine and exocrine function and pancreatic regeneration remained satisfactory and no additional pancreatic resection became necessary. These results indicate that 95% pancreatectomy may be tolerated without loss of pancreatic function.

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Abbreviations

HbAIc :

glycosylated haemoglobin

References

  1. Aynsley-Green A, Polak JM, Bloom SR (1981) Nesidioblastosis of the pancreas: Definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia. Arch Dis Child 56:496–508

    PubMed  Google Scholar 

  2. Bonner-Weir S, Trent DF, Weir GC (1983) Partial pancreatectomy in the rat and the subsequent defect in glucoseinduced insulin release. J Clin Invest 71:1544–1553

    PubMed  Google Scholar 

  3. Cornblaht M, Schwartz R (1976) Disorders of carbohydrate metabolism in infancy, 2nd edn. Saunders, Philadelphia, pp 180–186

    Google Scholar 

  4. Dunger DB, Burns C, Ghale GK (1988) Pancreatic exocrine and endocrine function after subtotal pancreatectomy for nesidioblastosis. J Pediatr Surg 23:112–115

    PubMed  Google Scholar 

  5. Gough MH (1984) The surgical treatment of hyperinsulinism in infancy and childhood. Br J Surg 71:75–78

    PubMed  Google Scholar 

  6. Heitz PU, Klöppel G, Häcki WH, Polak JM (1977) Nesidioblastosis: the pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Diabetes 26:632–642

    PubMed  Google Scholar 

  7. Hümmer HP, Böhles HJ, Giedl J, Schück R (1988) 7/8 Pankreasresektion bei Nesidioblastosis? Z Kinderchir 43:281–283

    PubMed  Google Scholar 

  8. Kamer JH van de, Bokkel HH ten, Weyers HA (1949) Rapid method for the determination of fat in faeces. J Biol Chem

  9. McFarland JO, Gillett FS, Rodger JZ (1964) Total pancreatectomy for hyperinsulinism in infants. Pediatr Surg 57:313–318

    Google Scholar 

  10. Pearson KW, Scott D, Torrance B (1977) Effects of partial surgical pancreatectomy in rats. Gastroenterology 72:469–473

    PubMed  Google Scholar 

  11. Spitz L, Buick RG, Grant DB (1986) Surgical treatment of nesidioblastosis. Pediatr Surg Int 1:26–29

    Google Scholar 

  12. Warden MJ, German JC, Buckingham BA (1988) The surgical management of hyperinsulinism in infancy due to nesidioblastosis. J Pediatr Surg 23:462–465

    PubMed  Google Scholar 

  13. WHO (1985) Expert commitee on diabetes mellitus, 2nd report. WHO Tech Rep Ser 727, Geneva

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Schönau, E., Deeg, K.H., Huemmer, H.P. et al. Pancreatic growth and function following surgical treatment of nesidioblastosis in infancy. Eur J Pediatr 150, 550–553 (1991). https://doi.org/10.1007/BF02072204

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  • DOI: https://doi.org/10.1007/BF02072204

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