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Burn wound closure using permanent skin replacement materials

  • World Progress In Surgery
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Abstract

Over the past decade, very significant advances in the development of clinically useful, permanent skin replacement materials have taken place. The most prominent and successful approaches to the physiological closure of an open wound have been either by creating a totally artificial dermal matrix material, by using culture techniques to expand cell populations for autologous transplantation, or by using a combination of these methods. As a result of substantial early progress in this field, permanent skin replacement materials as a treatment modality promise significant contributions to improved wound management and increased survival rates for patients with devastating soft tissue destruction such as massive burn injuries.

Résumé

Dans la dernière décennie, d'importants progrès dans le remplacement tissulaire permanent ont été accomplis. Les approches les plus séduisantes, qui réussissent le plus souvent, sont celles qui soit créent une matrice complètement artificielle, soit utilisent des techniques de culture cellulaire en vue de transplantations autologues ou encore qui combine plusieurs de ces méthodes. Du fait de ces progrès, le traitement par remplacement cutané permanent est une méthode pleine de promesses pour l'avenir. Elle pourrait améliorer le traitement des plaies et la survie des patients ayant eu des pertes tissulaires importantes, comme dans le cas de brûlures étendues.

Resumen

En la última década se han logrado avances de gran significación en el desarrollo de materiales de reemplazo permanente de la piel para uso clínico. Los aproches más destacados y útiles para el cierre fisiológico de una quemadura abierta han sido la creación de una matriz dérmica totalmente artificial mediante el uso de técnicas de cultivo para expander la población celular para trasplante autólogo o mediante la combinación de estos métodos. Como resultado del sustancial progreso inicial en este campo, los materiales para el reemplazo permanente de piel como modalidad terapéutica aparecen promisorios en cuanto a contribuciones significativas al mejor manejo de la herida y a un incremento en la tasa de sobrevida de pacientes con desvastadoras destrucciones de los tejidos blandos, tal como ocurre en las quemaduras masivas.

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Authors and Affiliations

  1. Surgical and Trauma Services, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, USA

    Ronald G. Tompkins M.D., Sc.D. & John F. Burke M.D.

  2. Shriners Burns Institute, Boston Unit, Boston, Massachusetts, USA

    Ronald G. Tompkins M.D., Sc.D. & John F. Burke M.D.

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  1. Ronald G. Tompkins M.D., Sc.D.
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  2. John F. Burke M.D.
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Tompkins, R.G., Burke, J.F. Burn wound closure using permanent skin replacement materials. World J. Surg. 16, 47–52 (1992). https://doi.org/10.1007/BF02067114

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