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Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology And Microbiology
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Abstract

Serum concentrations of immunoreactive von Willebrand factor (vWF) and soluble thrombomodulin (TM), and vWF multimer patterns were measured to assess endothelial function in patients with inflammatory intestinal diseases. In Crohn's disease and acute infective diarrhea, vWF concentrations were significantly higher than in normal controls. In all patient groups, multimeric analysis of vWF and the concentration of serum TM were not different from normal controls. The results indicate alteration of endothelial function in inflammatory intestinal disorders. They may be compatible with the presence of localized vasculitis, but indicate that systemic endothelial destruction does not occur in inflammatory bowel disease.

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Authors and Affiliations

  1. From the University Department of Medicine and Department of Infectious Disease, Royal Free Hospital and School of Medicine, Pond St., NW3 2QG, London, UK

    A. M. Sawyerr MD, M. S. Smith MB, BS, A. Hall BSc, M. Hudson MB, BS, C. R. Hay MD, A. J. Wakefield MB, BS, M. G. Brook MD, H. Tomura PhD & R. E. Pounder DSc(Med)

  2. University Department of Haematology, Royal Liverpool Hospital, Prescot St., L7 8XP, Liverpool, UK

    A. M. Sawyerr MD, M. S. Smith MB, BS, A. Hall BSc, M. Hudson MB, BS, C. R. Hay MD, A. J. Wakefield MB, BS, M. G. Brook MD, H. Tomura PhD & R. E. Pounder DSc(Med)

  3. Fuji Chemical Industries Limited, Toyama, Japan

    A. M. Sawyerr MD, M. S. Smith MB, BS, A. Hall BSc, M. Hudson MB, BS, C. R. Hay MD, A. J. Wakefield MB, BS, M. G. Brook MD, H. Tomura PhD & R. E. Pounder DSc(Med)

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  1. A. M. Sawyerr MD
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  2. M. S. Smith MB, BS
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Sawyerr, A.M., Smith, M.S., Hall, A. et al. Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases. Digest Dis Sci 40, 793–799 (1995). https://doi.org/10.1007/BF02064981

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  • DOI: https://doi.org/10.1007/BF02064981

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