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Effects of aurothioglucose and auranofin on radiographic progression in rheumatoid arthritis

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Summary

Radiographic films of 40 patients participating in a single centre patient blind study of auranofin versus aurothioglucose were evaluated in a random order by one reader. The two treatment groups were comparable with respect to number of erosions and total radiographic score at the start of the study. Only in the auranofin-treated patients was a statistically significant increase in the mean number of new erosions (p<0.001 at 6 months and p<0.01 at 12 months treatment, paired t-test) as well as in the total radiographic score (p<0.01 at 6 and 12 months treatment, paired t-test) observed. Results of this study confirm that parenteral gold compounds do retard radiographic progression of joint destruction in the treatment of rheumatoid arthritis. The effects on radiographic progression shown in this study are in agreement with other reports which, based on clinical and biochemical parameters, have shown that auranofin is somewhat less effective than the injectible gold salts.

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Authors and Affiliations

  1. Department of Rheumatology, University Hospital St. Radboud, Geert Grooteplein Zuid 8, 6500, HB Nijmegen, The Netherlands

    P. L. C. M. Van Riel & L. B. A. Van De Putte

  2. Department of Pharmacology, University Hospital St. Radboud, Nijmegen, The Netherlands

    F. W. J. Gribnau

  3. Spenshults Reumatiker-sjukhus, Oskarstrom, Sweden

    A. Larsen

Authors
  1. P. L. C. M. Van Riel
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  2. A. Larsen
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  3. L. B. A. Van De Putte
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  4. F. W. J. Gribnau
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Van Riel, P.L.C.M., Larsen, A., Van De Putte, L.B.A. et al. Effects of aurothioglucose and auranofin on radiographic progression in rheumatoid arthritis. Clin Rheumatol 5, 359–364 (1986). https://doi.org/10.1007/BF02054254

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  • DOI: https://doi.org/10.1007/BF02054254

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