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Therapeutic approaches in mixed cryoglobulinemia

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References

  1. Abe Y, Sakamoto T, Natsugane K, Okabe T, Takaoka T, Blasulting E, Smith WJ, Malchesky PS, Nose Y (1984) Cryoglobulin removal with cryofiltration in the treatment of cryoglobulinemia. Trans Am Soc Artif Intern Organs 30: 289

    PubMed  Google Scholar 

  2. Abel JJ, Rowntree LG, Turner BB (1914) Plasma removal with return of corpuscles (plasmapheresis). J Pharmacol Exp Ther 5: 625

    Google Scholar 

  3. Anderson DK, Means ED (1985) Iron-induced lipid preoxidation in spinal cord: protection with mannitol and methylprednisone. J Free Rad Biol Med 1: 59

    Google Scholar 

  4. Bayliss C, Brenner BM (1978) Mechanism of glucocorticoid-induced increase in glomerular filtration rate. Am J Physiol 234: 166

    Google Scholar 

  5. Bengtsson V, Larsson O, Lindstedt G, Svalander C (1975) Monoclonal IgG cryoglobulinemia with secondary development of glomerulonephritis and nephrotic syndrome. Q J Med 175: 491

    Google Scholar 

  6. Berkman EM, Orlin JB (1980) Use of plasmapheresis and partial plasma exchange in the management of patients with cryoglobulinemia. Transfusion 20: 171

    PubMed  Google Scholar 

  7. Betoume CI, Buge A, Decky H, Doria M, Dowinon E, Rancurel G (1980) The treatment of peripheral neuropathies in case of IgA myeloma and one of mixed cryoglobulinemia. Nouv Presse Med 9: 1369

    PubMed  Google Scholar 

  8. Bombardieri S, Maggiore Q, L'Abbate A, Bartolomeo F, Ferri C (1981) Plasma exchange in essential mixed cryoglobulinemia. Plas Ther Transfer Technol 2: 101

    Google Scholar 

  9. Brouet JC, Clauvel JP, Danon F, Klein M, Seligman M (1974) Biologic and clinical significance of cryoglobulins: a report of 86 cases. Am J Med 57: 775

    PubMed  Google Scholar 

  10. Cordonnier D, Vialtel P, Martin H (1977) Actualites Nephrologique de l'hopital Necker. Flammarion Med Sc, Paris, pp 349–385

    Google Scholar 

  11. Cordonnier D, Vialtel P, Renversez JL (1983) Renal disease in 18 patients with mixed type 2 IgM-IgG cryoglobulinemia. Adv Nephrol 12: 177

    Google Scholar 

  12. D'amico G, Ferrario F, Colasante, Bucci A (1985) Glomerulonephritis in EMCG. Proc Eur Dial Transplant Assoc 21: 527

    Google Scholar 

  13. Delaney VB, Fraley DS, Segal DP, Bruns FJ (1984) Plasmapheresis as sole therapy in patients with EMCG. Am J Kidney Dis 4: 75

    PubMed  Google Scholar 

  14. Delfraissy JF, Galanaud P, Balaroine JF, Wallon C, Dormont J (1984) Captopril and immune regulation. Kidney Int 25: 925

    PubMed  Google Scholar 

  15. DeVecci A, Montagnino G, Pozzi C, Tarantino A, Locatelli F, Ponticelli C (1983) Intravenous methylprednisolone pulse therapy in EMCG nephropathy. Clin Nephrol 19: 221

    PubMed  Google Scholar 

  16. Editorial (1982) Hazards of apheresis. Lancet II: 1025

  17. Evans TW, Nichols AJ, Shortland JR, Ward AM, Brown CB (1984) Acute renal failure in mixed cryoglobulinemia: precipitation and reversal by plasma exchange. Clin Nephrol 21: 287

    PubMed  Google Scholar 

  18. Fauci AS, Dale DC, Balow JE (1976) Corticosteroid therapy: mechanism of action and clinical consideration. Ann Intern Med 84: 304

    PubMed  Google Scholar 

  19. Ferri C, Mouconi L, Gremignai G, Migliorini P, Paleologo P, Fossela PV, Bombardieri S (1986) Treatment of renal involvement in MCG with prolonged plasma exchange. Nephron 43: 246

    PubMed  Google Scholar 

  20. Fleig C (1909) Autotransfusion of washed corpuscles as a blood washing procedure in toxemia. Bull Mens Acad Sci Let Montpellier 1: 4

    Google Scholar 

  21. Fontana A, Doll B, Joller H (1982) IgG-IgM cryoglobulinemia with a purpura-arthralgia-nephritis syndrome. Schweiz Med Wochenschr 112: 7

    PubMed  Google Scholar 

  22. Frank MM, Hamburger MI, Lawley TJ, Kimberley RP, Plots PH (1979) Defective reticuloendothelial system Fc receptor function in SLE. N Engl J Med 300: 518

    PubMed  Google Scholar 

  23. Geltner D (1986) Long-term treatment of mixed cryoglobulinemia (MCG). In: Ponticelli C, Minetti L, D'Amico G (eds) Antiglobulins, cryoglobulins and glomerulonephritis. Martinus Nijhoff, Dordrecht Boston, Lancaster, pp 273–286

    Google Scholar 

  24. Geltner D, Franklin EC, Frangione B (1980) Anti-idiotypic activity of the IgM fraction of cryoglobulins. J Immunol 125: 1530

    PubMed  Google Scholar 

  25. Geltner D, Kohn RW, Gorevic PD, Franklin EC (1981) The effect of combination therapy (steroids, immunosuppressives and plasmapheresis) on 5 mixed cryoglobulinemia patients with renal neurologic and vascular involvement. Arthritis Rheum 24: 1121

    PubMed  Google Scholar 

  26. Germain MJ, Anderson RW, Keane WF (1982) Renal disease in cryoglobulinemia type 2: response to therapy. A case report and review of the literature. Am J Nephrol 2: 221

    PubMed  Google Scholar 

  27. Gharavi AE, Campion G, Hughs GB (1984) Use of anti-idiotypic antibodies to demonstrate rheumatoid factor producing bone marrow cells in EMCG. Ann Rheum Dis 43: 651

    PubMed  Google Scholar 

  28. Gorevic PD, Kassab HG, Levo Y (1980) Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am J Med 69: 287

    PubMed  Google Scholar 

  29. Grey HM, Kohler PF (1973) Cryoimmunoglobulins. Semin Hematol 10: 87

    PubMed  Google Scholar 

  30. Gundgrandsson T, Hanson L, Herlitz H, Lindholm L, Nilsson LA (1981) Immunological changes in patients with precious malignant essential hypertension. Lancet I: 406

    Google Scholar 

  31. Hamburger MI, Gorevic PD, Lawly TJ, Franklin EC, Frank MM (1979) Mixed cryoglobulinemia: association of glomerulonephritis for defective reticulo-endothelial Fc receptor function. Trans Assoc Am Physicians 93: 104

    Google Scholar 

  32. Holdsworth SB, Bellomo R (1984) Differential effects of steroids on leukocytes-mediated glomerulonephritis in rabbit. Kidney Int 26: 162

    PubMed  Google Scholar 

  33. Horsman DE, Card RT, Skinnider LF (1983) Waldenstrom macroglobulinemia terminating in acute leukemia: a report of 3 cases. Am J Hematol 15: 484

    Google Scholar 

  34. Howert DA, Hene RJ, Struynenberg A, Kater L (1980) Effect of plasmapheresis, cortico steroids and cyclophosphamid in EM polyclonal cryoglobulinemia associated with glomerulonephritis. Proc Eur Dial Transplant Assoc 17: 650

    PubMed  Google Scholar 

  35. Invernizzi F, Galli M, Serino G, Monti G, Meroni PL, Granatieri C, Zanussi C (1983) Secondary and essential cryoglobulinemia. Frequency nosological classification and long-term follow-up. Acta Haematol (Basel) 70: 73

    Google Scholar 

  36. Jones JV, Cummings RH, Bacon PA, Evers J, Fraser ID, Bothamley J, Tribe CR, Davis P, Hughes GRV (1979) Evidence for therapeutic effect of plasmapheresis in patients with SLE. Q J Med 192: 555

    Google Scholar 

  37. L'Abbate A, Paciucci A, Bartolomeo F, Misefari V, Nobile F, Cerrai T, Maggiorri Q (1977) Selective removal of plasma cryoglobulins in cryoglobulinemia. Proc Eur Dial Transplant Assoc 14: 486

    PubMed  Google Scholar 

  38. Lalezari P, Kumar M (1980) Inhibition of cold insolubility of serum cryoglobulin by epsilon aminocaproic acid. Am J Med 68: 629

    PubMed  Google Scholar 

  39. Lerner AB, Barnum CP, Watson CJ (1947) Studies of cryoglobulins. The spontaneous precipitation of protein from serum in various disease state. Am J Med Sci 214: 410

    Google Scholar 

  40. Lockwood CM (1979) Lymphoma, cryoglobulinemia and renal disease. Kidney Int 16: 522

    PubMed  Google Scholar 

  41. Lockwood CM, Worlledge S, Nicholas A, Cotton C, Peters DK (1979) Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N Engl J Med 300: 524

    PubMed  Google Scholar 

  42. Maggiore A, L'Abbate F, Bartolomeo F, Gutrupi S (1986) Effects of cryoapheresis on plasma cryoglobulins and renal function in patients with EMC glomerulonephritis. In: Ponticelli C, Minetti L, D'Amico G (eds) Antiglobulins, cryoglobulins and glomerulonephritis. Martinus Nijhoff, Dordrecht Boston Lancaster, pp 251–264

    Google Scholar 

  43. Mathison DA, Condemi JJ, Leddy JP (1971) Purpura, arthralgia and IgM-IgG cryoglobulinemia with rheumatoid factor activity response to cyclophosphamid and splenectomy. Ann Intern Med 74: 383

    PubMed  Google Scholar 

  44. McLeod BC, Sassetti RJ (1980) Plasmapheresis with return of cryoglobulin-depleted autologous plasma (cryoglobulinpheresis) in cryoglobulinemia. Blood 55: 866

    PubMed  Google Scholar 

  45. Meltzer M, Franklin EC (1966) Cryoglobulinemia: a study of 29 patients. Am J Med 40: 828

    PubMed  Google Scholar 

  46. Nagslett A, McGiff JC, Colina-Chowrio J (1978) Interrelation of the renin-Kallikrein-Kinin system and renal prostaglandins in the conscious rat. Circ Res 43: 799

    PubMed  Google Scholar 

  47. Ooi, YM, Ooi BS, Vallota EH (1977) Circulating immunecomplexes after renal transplantation. J Clin Invent 60: 611

    Google Scholar 

  48. Pedersen-Bjegaard J, Ersboll J, Migind-Sorensen H (1985) Risk of acute nonlymphocytic leukemia and pre-leukemia in patients treated with cyclophosphamid for non Hodgkin's lymphomas. Ann Intern Med 103: 195

    PubMed  Google Scholar 

  49. Ponticelli C, Imbasciati B, Tarantino A, Pietro-Grande M (1977) Acute anuric glomerulonephritis in monoclonal cryoglobulinemia. Br Med J 1: 948

    Google Scholar 

  50. Ponticelli C, Montagnino G, Campise R, Baldassari A, Tarantino A (1986) Treatment of renal disease in EMCG. In: Ponticelli C, Minetti L, D'Amico G (eds) Antiglobulins, cryoglobulins and glomerulonephritis. Martinus Nijhoff. Dordrecht Boston Lancaster, pp 265–272

    Google Scholar 

  51. Putnam FW, Myake A (1956) Proteins in multiple myeloma. VI. Cryoglobulins. Arch Biochem Byophys 65: 39

    Google Scholar 

  52. Ristow SC, Griner PF, Abraham GN, Shoulson I (1976) Reversal of systemic manifestations of cryoglobulinemia. Arch Intern Med 136: 467

    PubMed  Google Scholar 

  53. Schab PJ, Fahey JL (1960) Treatment of Waldenstrom macroglobulinemia by plasmapheresis. N Engl J Med 263: 574

    PubMed  Google Scholar 

  54. Shumak KH, Rock GA (1984) Therapeutic plasma exchange. N. Engl J Med 310: 762

    PubMed  Google Scholar 

  55. Solomon A, Fahey JL (1963) Plasma pheresis therapy in macroglobulinemia. Ann Intern Med 58: 789

    PubMed  Google Scholar 

  56. Tarantino A, De Vecchi A, Montagnino G, Imbasciati E, Mihatsch MJ, Zollinger HV, Barbiano Di Belgiojosa, Busnach G, Ponticelli C (1981) Renal disease in EMCG. Long term follow up of 44 patients. Q J Med 197: 1

    Google Scholar 

  57. Verroust P, Mery JPH, Morel-Maroger L, Clauvel JP, Richet G (1971) Les lesion glomerulaires de gammopathies monoclonales et des cryoglobulinemies idiopathiques IgG-IgM. Actual Nephrol Hop Necker, Flammarion, Paris, p 167

    Google Scholar 

  58. Waldenstrom JG (1980) Plasmapheresis-blood letting revived and refined. Acta Med Scand 208: 1

    PubMed  Google Scholar 

  59. Weiler JM, Packard BD (1982) Methylprednisolone inhibits the alternative and amplification pathways of complement. Infect Immun 38: 12

    Google Scholar 

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Geltner, D. Therapeutic approaches in mixed cryoglobulinemia. Springer Semin Immunopathol 10, 103–113 (1988). https://doi.org/10.1007/BF02054027

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