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The comparison of four strains of Coccidioides immitis with diverse histories

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Summary

By the criterion of lethality in mice, a strain ofCoccidioides immitis recently isolated from a most devastating form of human coccidioidomycosis was of no greater virulence than another isolated from a much less severe case or even one cultured from soil fifteen years ago and which presumably had caused seven self-limited, benign cases of primary coccidioidomycosis. There was no enhancement of virulence to mice by twelve passages of a relatively avirulent strain which had been recovered twenty-one years ago from a fatal human case.

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Literature

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Author notes

  1. Lorraine Friedman

    Present address: Department of Microbiology, Tulane University, School of Medicine, New Orleans, Louisiana

Authors and Affiliations

  1. Naval Biological Laboratory, Department of Bacteriology and School of Public Health, University of California, Berkeley, California, USA

    Lorraine Friedman & C. E. Smith

Authors
  1. Lorraine Friedman
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  2. C. E. Smith
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Additional information

This work was supported in part by a contract between the University of Calif., Department of Bacteriology and the Office of Naval Research and part under the sponsorship of the Commission on Acute Respiratory Diseases of the Armed Forces Epidemiological Board and was supported by the Office of the Surgeon General, Department of the Army.

The opinions contained in this report are not to be construed as reflecting the views of the Navy Department or the Naval Service at large (Article 1252, U.S. Navy Regulations, 1948).

The authors gratefully acknowledge the photographic service of Mr.William F. Hetrick and the technical services of Mr.Robert J. Berman.

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Friedman, L., Smith, C.E. The comparison of four strains of Coccidioides immitis with diverse histories. Mycopathologia et Mycologia Applicata 8, 47–53 (1957). https://doi.org/10.1007/BF02053117

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  • DOI: https://doi.org/10.1007/BF02053117

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