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Metachronous colorectal cancer in young patients: Expression of the hereditary nonpolyposis colorectal cancer syndrome?

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Diseases of the Colon & Rectum

Abstract

The cumulative incidence rate of metachronous colorectal cancer in patients younger than 40 years of age at diagnosis of the primary cancer has been shown to be 30 percent. Metachronous colorectal cancer is predominantly located in the right colon with a decreasing frequency toward the rectum. The risk of developing a metachronous colorectal cancer was found to be 16–29 times increased when compared with the risk of having a primary colorectal cancer. Because of the resemblance between characteristics of metachronous colorectal cancer and the features of hereditary nonpolyposis colorectal cancer (HNPCC), it is proposed that young colorectal cancer patients developing metachronous colorectal cancer could in fact be HNPCC patients.

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References

  1. Kiefer PJ, Thorson AG, Christensen MA. Metachronous colorectal cancer: time interval to presentation of a metachronous cancer. Dis Colon Rectum 1986;29:378–82.

    PubMed  Google Scholar 

  2. Nava HR, Pagana TJ. Postoperative surveillance of colorectal carcinoma. Cancer 1982;49:1043–7.

    PubMed  Google Scholar 

  3. Luchtefeld MA, Ross DS, Zander JD, Folse JR. Late development of metachronous colorectal cancer. Dis Colon Rectum 1987;30:180–4.

    PubMed  Google Scholar 

  4. Welch JP. Multiple colorectal tumors: an appraisal of natural history and therapeutic options. Am J Surg 1981;142:274–80.

    PubMed  Google Scholar 

  5. Ekelund GR, Pihl B. Multiple carcinomas of the colon and rectum. Cancer 1974;33:1630–4.

    PubMed  Google Scholar 

  6. Moertel CG, Bargen JA, Dockerty MB. Multiple carcinomas of the large intestine. Gastroenterology 1958;34:85–98.

    PubMed  Google Scholar 

  7. Rosenthal I, Baronofsky ID. Prognostic and therapeutic implications of polyps in metachronous colic carcinoma. JAMA 1960;172:37–41.

    PubMed  Google Scholar 

  8. Thomas JF, Dockerty MB, Waugh JM. Multiple primary carcinomas of the large intestine. Cancer 1948;1:564–73.

    Google Scholar 

  9. Ginzburg L, Dreiling DA. Successive independent (metachronous) carcinomas of the colon. Ann Surg 1956;143:117–20.

    PubMed  Google Scholar 

  10. Devitt JE, Roth-Moyo LA, Brown FN. The significance of multiple adenocarcinomas of the colon and rectum. Ann Surg 1969;169:364–7.

    PubMed  Google Scholar 

  11. Bülow S. Colorectal cancer in patients less than 40 years of age in Denmark, 1943–1967. Dis Colon Rectum 1980;23:327–36.

    PubMed  Google Scholar 

  12. Heald RJ, Lockhart-Mummery HE. The lesion of the second cancer of the large bowel. Br J Surg 1972;59:16–9.

    PubMed  Google Scholar 

  13. Bussey HJR, Wallace MH, Morson BC. Metachronous carcinoma of the large intestine and intestinal polyps. Proc R Soc Med 1967;60:208–10.

    PubMed  Google Scholar 

  14. Traviesco CR Jr, Knoepp LF Jr, Hanley PH. Multiple adenocarcinomas of the colon and rectum. Dis Colon Rectum 1972;15:1–6.

    PubMed  Google Scholar 

  15. Agrez MV, Ready R, Ilstrup D, Beart RW Jr. Metachronous colorectal malignancies. Dis Colon Rectum 1982;25:569–74.

    PubMed  Google Scholar 

  16. Bülow S, Svendsen LB, Mellemgaard A. Metachronous colorectal carcinoma. Br J Surg 1990;77:502–5.

    PubMed  Google Scholar 

  17. Danish Cancer Registry. Cancer incidence in Denmark 1985 Danish Cancer Society. Copenhagen 1988.

  18. Coleman M, Douglas A, Hermon C, Peto J. Cohort study analysis with a FORTRAN computer program. Int J Epidemiol 1986;15:134–7.

    PubMed  Google Scholar 

  19. Rothman KJ, Boice JD. Epidemiologic analysis with a programmable calculator. Boston: Epidemiology Resources, 1982.

    Google Scholar 

  20. Dixon WJ, ed. BMDP statistical software, program 2 L. Berkeley, Los Angeles: University of California Press, 1985.

    Google Scholar 

  21. Mecklin J-P., Järvinen HJ, Peltokallio P. Cancer family syndrome: genetic analysis of 22 Finnish kindreds. Gastroenterology 1986;90:328–33.

    PubMed  Google Scholar 

  22. Mecklin J-P. Frequency of hereditary colorectal carcinoma. Gastroenterology 1987;93:1021–5.

    PubMed  Google Scholar 

  23. Bülow S, Svendsen LB, Danes BS. To familier med cancerfamiliesyndromet. Ugeskr Laeger 1981;143:2716–8.

    PubMed  Google Scholar 

  24. Lynch HT, Kimberling W, Albano WA,et al. Hereditary nonpolyposis colorectal cancer (Lynch Syndromes 1 and 11). Cancer 1985;56:934–8.

    PubMed  Google Scholar 

  25. Mecklin J-P. Cancer family syndrome: studies on the hereditary non-polypsosi colorectal cancer syndromes. (Thesis.) Helsinki University Central Hospital, Department of Surgery, 1987.

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Authors and Affiliations

  1. Departments of Surgical Gastroenterology, Bispebjerg and Hvidovre Hospitals, Copenhagen, Denmark

    Lars Bo Svendsen M.D., Steffen Bülow Ph.D. & Anders Mellemgaard M.D.

  2. Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark

    Lars Bo Svendsen M.D., Steffen Bülow Ph.D. & Anders Mellemgaard M.D.

Authors
  1. Lars Bo Svendsen M.D.
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  2. Steffen Bülow Ph.D.
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  3. Anders Mellemgaard M.D.
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Svendsen, L.B., Bülow, S. & Mellemgaard, A. Metachronous colorectal cancer in young patients: Expression of the hereditary nonpolyposis colorectal cancer syndrome?. Dis Colon Rectum 34, 790–793 (1991). https://doi.org/10.1007/BF02051072

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