Skip to main content

Advertisement

SpringerLink
Log in

Colonic histoplasmosis in acquired immunodeficiency syndrome

Report of two cases

  • Case Reports
  • Published:
Diseases of the Colon & Rectum

Abstract

Colonic histoplasmosis is a rare entity. There have been four previous reported cases within the population of patients with human immunodeficiency virus (HIV) infection. Because of the increasing incidence of HIV infection within regions where histoplasmosis is endemic, this condition may become more common. Gastrointestinal histoplasmosis has protean clinical manifestations, and symptoms are often nonspecific. Any patient with HIV infection who has unexplained GI symptoms should undergo evaluation for possible histoplasmosis. Aggressive long-term amphotericin B therapy has been effective in HIV patients with histoplasmosis. Resection or diversion of symptomatic colonic strictures caused by histoplasmosis may be necessary in addition to medical therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Darling ST. A protozoan general infection producing pseudotubercles in the lungs and focal necrosis in the liver, spleen, and lymphatics. JAMA 1906;46:1283–5.

    Google Scholar 

  2. Darling ST. Histoplasmosis: a fatal infectious disease resembling kala-azar found among natives of tropical America. Arch Intern Med 1908;2:107–23.

    Google Scholar 

  3. Henderson RG, Pinkerton H, Moore LT. Histoplasma capsulatum as a cause of chronic ulcerative enteritis. JAMA 1942;118:865–89.

    Google Scholar 

  4. Haggerty CM, Britton MC, Dorman JM, Marzon MA. Gastrointestinal histoplasmosis in suspected acquited immune deficiency syndrome. West J Med 1985;143:244–6.

    PubMed  CAS  Google Scholar 

  5. Keelan C, Imbert M. Colonic histoplasmosis simulating Crohn's disease in a patient with AIDS. Bol Asoc Med P R 1988;80:248–50.

    PubMed  Google Scholar 

  6. Cappell MS, Mandell W, Grimes MM, Neu HC. Gastrointestinal histoplasmosis. Dig Dis Sci 1988;33:353–60.

    Article  PubMed  CAS  Google Scholar 

  7. Goodwin RA, Shapiro JL, Thurman GH, Thurman SS, Des Pres RM. Disseminated histoplasmosis: clinical and pathologic correlations. Medicine 1980;59:1–33.

    PubMed  Google Scholar 

  8. Davies S, Khan M, Sarosi G. Disseminated histoplasmosis in immunologically suppressed patients: occurrence in a nonendemic area. Am J Med 1978;64:94–100.

    Article  PubMed  CAS  Google Scholar 

  9. Kauffman CA, Israel KS, Smith JW, White AC, Schwarz J, Brooks GF. Histoplasmosis in immunosuppressed patients. Am J Med 1978;64:923–32.

    Article  PubMed  CAS  Google Scholar 

  10. Wheat LJ, Slama TG, Norton JA,et al. Risk factors for disseminated or fatal histoplasmosis. Ann Intern Med 1982;96:159–63.

    CAS  PubMed  Google Scholar 

  11. Miller DP, Everett ED. Gastrointestinal histoplasmosis. J Clin Gastroenterol 1979;1:233–6.

    Article  PubMed  CAS  Google Scholar 

  12. Lee SH, Barnes WG, Hodges GR, Dixon A. Perforated granulomatous colitis caused byHistoplasma capsulatum. Dis Colon Rectum 1985;28:171–6.

    PubMed  CAS  Google Scholar 

  13. Sturim HS, Kouchoukos NT, Ahlvin RC. Gastrointestinal manifestation of disseminated histoplasmosis. Am J Surg 1965;110:435.

    Article  PubMed  CAS  Google Scholar 

  14. Bank S, Trey C, Gans I, Marks IN, Groll A. Histoplasmosis of the small bowel with “giant” intestinal villi and secondary protein losing enteropathy. Am J Med 1965;39:492–501.

    Article  PubMed  CAS  Google Scholar 

  15. Loyd J, Des Prez R, Goodwin R. Histoplasma capsulatum. In: Mardell G,et al. eds. Principles and practice of infectious disease. 2nd ed. New York: Churchill Livingstone, 1990:1989–98.

    Google Scholar 

  16. Wheat J, French MLV, Kohler RB,et al. The diagnostic laboratory test for histoplasmosis: analysis of experience in a large urban outbreak. Ann Intern Med 1982;97:680–5.

    PubMed  CAS  Google Scholar 

  17. Buechner HA, Seabury JH, Campbell CC, George LV, Kaufman L, Kaplan W. The current status of serologic, immunologic, and skin tests in the diagnosis of pulmonary mycosis. Chest 1973;63:259–70.

    PubMed  Google Scholar 

  18. McKinsey DS, Gupta MR, Riddler SA, Driks MR, Smith DL, Kurtin PJ. Long-term amphotericin B therapy for disseminated histoplasmosis in patients with AIDS. Ann Intern Med 1989;111:655–9.

    PubMed  CAS  Google Scholar 

  19. Kurtin PJ, McKinsey DS, Smith DL, Gupta MR, Driks MR. Histoplasmosis in patients with AIDS, hematologic and bone marrow manifestations. Am J Clin Pathol 1990;93:367–72.

    PubMed  CAS  Google Scholar 

  20. Wheat LJ, Slama TG, Zeckel ML. Histoplasmosis in AIDS. Am J Med 1985;78:203–10.

    Article  PubMed  CAS  Google Scholar 

  21. Bonner JR, Alexander WJ, Dismukes WE,et al. Disseminated histoplasmosis in patients with AIDS. Arch Intern Med 1984;144:2177–81.

    Article  Google Scholar 

  22. Johnson PC, Khardori N, Najjar A, Butt F, Mansell PWA, Sarosi GA. Progressive disseminated histoplasmosis in patients with AIDS. Am J Med 1988;85:152–8.

    Article  PubMed  CAS  Google Scholar 

  23. Graybill JR. Histoplasmosis and AIDS. J Infect Dis 1988;158:623–6.

    PubMed  CAS  Google Scholar 

  24. Laughlon BE. Prevalence of enteric pathogens in homosexual men with and without AIDS. Gastroenterology 1988;94:984–93.

    PubMed  Google Scholar 

  25. Smith PD, Lane HC, Gill VJ,et al. Intestinal infection in patients with AIDS. Ann Intern Med 1988;108:328–33.

    PubMed  CAS  Google Scholar 

  26. Alterman DD, Cho KC. Histoplasmosis involving the omentum in an AIDS patient, CT demonstration. J Comput Assist Tomogr 1988;12:664–5.

    PubMed  CAS  Google Scholar 

  27. Reddy P, Gorelick DF, Brasher CA, Larsh H. Progressive disseminated histoplasmosis as seen in adults. Am J Med 1970;48:629–36.

    Article  PubMed  CAS  Google Scholar 

  28. Haws CC, Long RF, Caplan GE. Histoplasmosis capsulatum as a cause of ileocolitis. AJR 1977;128:692–4.

    PubMed  CAS  Google Scholar 

  29. United States Public Health Service Cooperative Mycoses Study. Course and prognosis of untreated histoplasmosis. JAMA 1961;177:292–6.

    Google Scholar 

  30. Peppercorn MA. Enteric infections in homosexual men with and without AIDS. Contemp Gastroenterol 1989;2:23–32.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Colon-Rectal Surgery, and Department of Infectious Disease, Research Hospital, Kansas City, Missouri

    Bruce D. Graham M.D., David S. McKinsey M.D., Michael R. Driks M.D. & David L. Smith M.D.

Authors
  1. Bruce D. Graham M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David S. McKinsey M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael R. Driks M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David L. Smith M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Graham, B.D., McKinsey, D.S., Driks, M.R. et al. Colonic histoplasmosis in acquired immunodeficiency syndrome. Dis Colon Rectum 34, 185–190 (1991). https://doi.org/10.1007/BF02049996

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02049996

Key words

Search

Navigation