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Human papillomavirus type-related DNA and c-myc oncogene alterations in colon cancer cell lines

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Diseases of the Colon & Rectum

Abstract

Although squamous-cell epithelium is the most frequent target site of human papillomavirus (HPV) infection, a similar infection is demonstrated in columnar epithelial cells in this paper. The papillomavirus expression in three cell lines was detected in colorectal adenocarcinoma of Chinese patients. The HPV-16 and HPV-18 DNA sequences were found in colorectal cancer cell lines, which might suggest the correlation of HPV to the etiology of colorectal cancers. In addition, c-myc oncogene was identified by amplification in all three colorectal cancer cell lines, but only normal germ-line fragments were found in control tissue. The correlation between HPV and c-myc,and the implications of these findings in colorectal cancers are also discussed

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC

    Jhy-Young Cheng M.D., D.M.Sc. & Jih-Chang Lin M.D.

  2. Division of Colon and Rectal Surgery, Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC

    Ching-Liang Meng M.D., D.M.Sc., Chung-Faye Chao M.D., Ph.D. & Shun-Der Gau M.D., M.S.

Authors
  1. Jhy-Young Cheng M.D., D.M.Sc.
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  2. Ching-Liang Meng M.D., D.M.Sc.
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  3. Chung-Faye Chao M.D., Ph.D.
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  4. Shun-Der Gau M.D., M.S.
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  5. Jih-Chang Lin M.D.
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Additional information

This research was supported by Grant NSC 77-0609-B016-01 from the National Science Council, R.O.C.

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Cheng, JY., Meng, CL., Chao, CF. et al. Human papillomavirus type-related DNA and c-myc oncogene alterations in colon cancer cell lines. Dis Colon Rectum 34, 469–474 (1991). https://doi.org/10.1007/BF02049931

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