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Effects of diclofenac sodium on intestinal anastomotic healing

Experimental study on the small intestine of rabbits

  • Published:
Diseases of the Colon & Rectum

Abstract

To study the possible effects of diclofenac sodium on intestinal anastomoses, 48 rabbits were submitted to surgery consisting of two single-layer ileal anastomoses performed with separate propylene 5-0 sutures. The animals were divided at random into two groups (test and control). The animals in the test group were given intramuscular injections of diclofenac sodium at the dose of 3 mg/ kg body weight at 24-hour intervals, and the control animals were given injections of an identical amount of 0.9 percent saline. The animals were sacrificed on the 3rd, 7th, and 14th postoperative days for macroscopic evaluation of the peritoneal cavity and of the anastomoses, tensile strength measurement, hydroxyproline determination, and histopathologic examination. The following results were observed: anastomotic dehiscence followed by peritonitis and death in five test animals (20.83 percent) and no control animals; decreased anastomotic tensile strength on the 7th day in test animals (P<0.05); delayed acute inflammatory response and onset of fibroblast proliferation in the test group; and similar hydroxyproline levels in both groups. On the basis of the results obtained, we conclude that diclofenac sodium had a negative effect on intestinal anastomotic healing.

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Authors and Affiliations

  1. Department of Surgery, Orthopedics and Traumatology, University Hospital, Faculty of Medicine of RibeirÃo Preto, USP, 14049, RibeirÃo Preto, SÃo Paulo, Brazil

    JoÃo Batista de Sousa M.D., Edson Garcia Soares M.D. & Francisco Aprilli M.D.

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  1. JoÃo Batista de Sousa M.D.
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  2. Edson Garcia Soares M.D.
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  3. Francisco Aprilli M.D.
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Batista de Sousa, J., Garcia Soares, E. & Aprilli, F. Effects of diclofenac sodium on intestinal anastomotic healing. Dis Colon Rectum 34, 613–617 (1991). https://doi.org/10.1007/BF02049903

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