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Immunohistochemical localization of carcinoembryonic antigen as a predictor of lymph node status in submucosa-invasive colorectal carcinoma

  • Original Contributions
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Diseases of the Colon & Rectum

Abstract

PURPOSE: Submucosa-invasive colorectal carcinoma is a colorectal carcinoma extending only into the submucosal layer. To clarify the metastatic potential of submucosa-invasive colorectal carcinoma, we studied the relationship between the immunohistochemical staining pattern of carcinoembryonic antigen (CEA) and that of lymphatic invasion/ lymph node metastasis. METHODS: We investigated 49 submucosa-invasive colorectal carcinomas resected surgically or endoscopically. CEA distribution patterns of the neoplastic tissues were divided into three patterns: Pattern 1 = luminal type; Pattern 2 = apical cytoplasmic type; and Pattern 3 = diffuse cytoplasmic type. We also observed the submucosal stromal staining of CEA. RESULTS: Lymphatic invasion and lymph node metastasis were found in 48.8 percent (21/43) and 11.6 percent (5/43) of the Pattern 2/Pattern 3 cases, whereas these were seen in none (0/6) of Pattern 1 cases. Lymphatic invasion and lymph node metastasis were found in 63.3 percent (19/30) (chi-squared =21.94;P <0.001) and 16.7 percent (5/30) of the positive stromal CEA cases, whereas these were seen in 10.5 percent (2/19) and none (0/14) of the negative stromal CEA cases, respectively. CONCLUSION: Pattern 2/Pattern 3 and stromal CEA can be predictors of the lymph node metastasis with 11.6 percent and 16.7 percent risks.

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References

  1. Wolff WI, Shinya H. Definitive treatment of “malignant” polyps of the colon. Ann Surg 1975;182:516–24.

    PubMed  Google Scholar 

  2. Shatney CH, Lober PH, Gilbertsen VA, Sosin H. The treatment of pedunculated adenomatous colorectal polyps with focal cancer. Surg Gynecol Obstet 1974;139:845–50.

    PubMed  Google Scholar 

  3. Winawer SJ, Witt TR. Cancer in a colonic polyp, or malignant colonic adenomas: is polypectomy sufficient? Gastroenterology 1981;81:625–6.

    Google Scholar 

  4. Colacchio TA, Forde KA, Scantlebury VP. Endoscopic polypectomy: inadequate treatment for invasive colorectal carcinoma. Ann Surg 1981;194:704–7.

    PubMed  Google Scholar 

  5. Sugihara K, Muto T, Morioka Y. Management of patients with invasive carcinoma removed by colonoscopic polypectomy. Dis Colon Rectum 1989;32:829–34.

    PubMed  Google Scholar 

  6. Wilcox GM, Anderson PB, Colacchio TA. Early invasive carcinoma in colonic polyps. Cancer 1986;57:160–71.

    PubMed  Google Scholar 

  7. Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinoma by immunological tolerance and absorption techniques. J Exp Med 1965;121:439–62.

    PubMed  Google Scholar 

  8. Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med 1965;122:467–81.

    PubMed  Google Scholar 

  9. Taguchi T, Kijima H, Mitomi T, Osamura Y. Immunohistochemical study of colorectal adenocarcinomas and adenomas with antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, α-tubulin and secretary component (SC). Gastroenterologia Japonica 1991;26: 294–302.

    PubMed  Google Scholar 

  10. Isaacson P, LeVann HP. The demonstration of carcino-embryonic antigen in colorectal carcinoma and colonic polyps using an immunoperoxidase technique. Cancer 1976;38:1348–56.

    PubMed  Google Scholar 

  11. Goldenberg DM, Sharkey RM, Primus FJ. Carcinoembryonic antigen in histopathology: immunoperoxidase staining of conventional tissue sections. J Natl Cancer Inst 1976;57:11–22.

    PubMed  Google Scholar 

  12. Midiri G, Amatani C, Benedetti M. CEA tissue staining in colorectal cancer patients. Cancer 1985;55:2624–9.

    PubMed  Google Scholar 

  13. Phil E, McNaughtan J, Ma J, Ward HA, Nairn RC. Immunohistological patterns of carcinoembryonic antigen in colorectal carcinoma: correlation with staging and blood levels. Pathology 1980;12:7–13.

    PubMed  Google Scholar 

  14. Wagener C, Wallraf RM, Niseen S, Groner J, Breuer H. Localization and concentration of carcinoembryonic antigen (CEA) in gastrointestinal tumors: correlation with CEA levels in plasma. J Natl Cancer Inst 1981;67:539–47.

    PubMed  Google Scholar 

  15. Hamada Y, Yamaura M, Hioki K, Yamamoto M, Nagura H, Watanabe K. Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Cancer 1985;55:136–41.

    PubMed  Google Scholar 

  16. Tabuchi Y, Deguchi H, Saitoh Y. Carcinoembryonic antigen and carbohydrate antigen 19-9 levels of peripheral and draining venous blood in colorectal cancer patients. Cancer 1988;62:1605–13.

    PubMed  Google Scholar 

  17. O'Brien MJ, Zamcheck N, Burke B, Kirkham SE, Saravis CA, Gottlieb LS. Immunocytochemical localization of carcinoembryonic antigen in benign and malignant colorectal tissues. Am J Clin Pathol 1981;75:283–90.

    PubMed  Google Scholar 

  18. Wiggers T, Arends JW, Verstijnen C, Moerkerk PM, Bosman FT. Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue. Br J Cancer 1986;54:409–14.

    PubMed  Google Scholar 

  19. Ahnen DJ, Nakane PK, Brown WR. Ultrastructual localization of carcinoembryonic antigen in normal intestine and colon cancer. Cancer 1982;49:2077–90.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, 259-11, Kanagawa, Japan

    Nobuhiro Tokunaga M.D., Takashi Noto M.D., Sotaro Sadahiro M.D., Tomoo Tajima M.D. & Toshio Mitomi M.D.

  2. Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan

    Hiroshi Kijima M.D. & Yoshiyuki Osamura M.D.

Authors
  1. Nobuhiro Tokunaga M.D.
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  2. Hiroshi Kijima M.D.
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  3. Takashi Noto M.D.
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  4. Yoshiyuki Osamura M.D.
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  5. Sotaro Sadahiro M.D.
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  6. Tomoo Tajima M.D.
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  7. Toshio Mitomi M.D.
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Additional information

Read at the meeting of the Japanese Society of Gastroenterological Surgery, Tokyo, Japan, February 24 to 25, 1994.

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Tokunaga, N., Kijima, H., Noto, T. et al. Immunohistochemical localization of carcinoembryonic antigen as a predictor of lymph node status in submucosa-invasive colorectal carcinoma. Dis Colon Rectum 38, 842–847 (1995). https://doi.org/10.1007/BF02049841

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  • DOI: https://doi.org/10.1007/BF02049841

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