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Morbidity of subtotal colectomy in patients with severe ulcerative colitis unresponsive to cyclosporin

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Diseases of the Colon & Rectum

Abstract

PURPOSE: The aim of this study was to document the morbidity of urgent subtotal colectomy and ileostomy in patients with severe ulcerative colitis who failed cyclosporin treatment. METHODS: We reviewed the charts of patients with severe ulcerative colitis who did not respond to cyclosporin treatment and underwent urgent subtotal colectomy and Brooke ileostomy at two inflammatory bowel disease centers over the 12-month period ending April 1994. RESULTS: Fourteen patients (6 males; mean age, 34 years) required an urgent subtotal colectomy and Brooke ileostomy after failing treatment with cyclosporin. There were no deaths. Eight patients (57 percent) developed postoperative complications, which included ileus (3), deep vein thrombosis (2), wound infection (2), and partial dehiscence of rectal stump (1). Mean length of postoperative hospital stay was 8.8 days. CONCLUSIONS: These initial data suggest that cyclosporin treatment may not influence the safety of urgent surgical treatment in severe ulcerative colitis.

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California

    Phillip R. Fleshner M.D.

  2. Inflammatory Bowel Disease Center, Cedars- Sinai Medical Center, Los Angeles, California

    Scott E. Plevy M.D. & Stephan R. Targan M.D.

  3. Department of General Surgery, University of Chicago Medical Center, Chicago, Illinois

    Fabrizio Michelassi M.D. & Michele Rubin M.S.N.

  4. Department of Medicine, University of Chicago Medical Center, Chicago, Illinois

    Stephen B. Hanauer M.D.

Authors
  1. Phillip R. Fleshner M.D.
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  2. Fabrizio Michelassi M.D.
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  3. Michele Rubin M.S.N.
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  4. Stephen B. Hanauer M.D.
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  5. Scott E. Plevy M.D.
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  6. Stephan R. Targan M.D.
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Fleshner, P.R., Michelassi, F., Rubin, M. et al. Morbidity of subtotal colectomy in patients with severe ulcerative colitis unresponsive to cyclosporin. Dis Colon Rectum 38, 1241–1245 (1995). https://doi.org/10.1007/BF02049146

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