Skip to main content
SpringerLink
Log in

Separation of carrier-free47Sc from titanium targets

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The radiochemical separation of no-carrier-added (NCA)47Sc fromnatTi targets has been studied. Scandium-47, a medium-energy β-emitter, is intended for use with labelled tumor associated monoclonal antibodies for radiotherapy. Several radiochemical methods for the separation of NCA47Sc from macroquantities of titanium and other impurities were tested. Four different procedures based on ion exchange, solvent extraction and extraction chromatography are reported. For each method, parameters such as the distribution coefficient, kinetics and recoveries are reported. The selective separation can be performed rapidly by all methods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. C. SRIVASTAVA, L. F. MAUSNER (Eds), Radiolabelled Monoclonal Antibodies Chemical, Diagnostic and Therapeutic Investigations, Nucl. Med. Biol., 13 (1986) 303.

  2. L. F. MAUSNER, R. F. STRAUB, S. C. SRIVASTAVA, in: Radiolabelled Monoclonal Antibodies for Imaging and Therapy, NATO-ASI Serie A, Vol. 152, S. C. SRIVASTAVA (Ed.), Plenum Press, New York 1988, p. 149.

    Google Scholar 

  3. E. S. GLADNEY, W. E. GOODE, Int. J. Appl. Radiation Isotopes, 30 (1979) 65.

    Article  Google Scholar 

  4. M. YAGI, K. KONDO, Int. J. Appl. Radiation Isotopes, 28 (1977) 463.

    Article  Google Scholar 

  5. R. I. WALTER, J. Inorg. Nucl. Chem., 6 (1958) 63.

    Article  Google Scholar 

  6. K. L. KOLSKY, L. PIETRELLI, F. MAUSNER, Int. J. Appl. Radiation Isotopes, (in press).

  7. P. MARKL, E. R. SCHMID, in: Extraction Chromatography, T. BRAUN G. GHERSINI (Eds), Elsevier, Amsterdam, 1975, p. 45.

    Google Scholar 

  8. F. W. STRELOW, Anal. Chem., 56 (1984) 1053.

    Article  Google Scholar 

  9. J. MINCZEWSKI, J. CHAWASTOWSKA, R. DYBCZYNSKI, in: Separation and Preconcentration Methods in Inorganic Trace Analysis, E. Horwood, Chichester, 1982.

    Google Scholar 

  10. P. MEUNIER, Compt. rend., 199 (1934) 1250.

    Google Scholar 

  11. N. H. FURMAN, W. B. MASON, J. S. PEKOLA, Anal. Chem., 21 (1949) 1325.

    Article  Google Scholar 

  12. J. STARY, J. SMIZANSKY, Anal. Chim. Acta, 29 (1963) 546.

    Google Scholar 

  13. P. G. BEREZHKO, S. S. KOROVIN, K. I. PETROV, A. M. REZNIK, Russian J. Inorg. Chem., 13 (1968) 552.

    Google Scholar 

  14. P. KOREBEL, A. MEYER, in: Proc. Intern. Solvent Extraction Conference (ISEC), 1974, Lyon, p. 2095.

Download references

Author information

Authors and Affiliations

  1. ENEA, DRI-MEPIS, CRE Casaccia, Via Anguillarese, 302-00060, Rome, Italy

    L. Pietrelli

  2. Medical Department, Brookhaven National Laboratory, 11973, Upton, New York, USA

    L. F. Mausner & K. L. Kolsky

Authors
  1. L. Pietrelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. F. Mausner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. L. Kolsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pietrelli, L., Mausner, L.F. & Kolsky, K.L. Separation of carrier-free47Sc from titanium targets. Journal of Radioanalytical and Nuclear Chemistry, Articles 157, 335–345 (1992). https://doi.org/10.1007/BF02047448

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02047448

Keywords

Search

Navigation