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Zur Technik und Physiologie heterotop transplantierter Herzen

Technique and physiology of heterotopic heart transplants

  • Published:
Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

For testing immunosuppressive agents in dogs the heart of a donor is heterotopically transplanted into the abdomen of a recipient. The operative technique is described in detail. Simultaneously measured pressure and flow to the transplant and their alterations while injecting cardiologically important drugs are discussed. In chronic experiments the time of a rejection crisis will be determined early by a number of parameters: blood pressure, coronary flow, change in myocardial contractility and alterations in certain enzyme systems in the blood.

Zusammenfassung

In einer Versuchsreihe an Hunden zur Erprobung immunsuppressiver Substanzen wird ein Herz in das Abdomen eines Empfängers heterotop implantiert. Die operative Technik wird detailliert beschrieben. Simultan werden Druck und Fluß in das Transplantat gemessen und ihre Änderungen nach Injektion kardiologisch wichtiger Medikamente diskutiert. Im Langzeitversuch soll der Zeitpunkt der Abstoßung durch Parameter, wie Druck, Durchfluß, Änderung der Kontraktionskraft und Verschiebungen im Enzymmuster, frühzeitig erkannt werden.

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Authors and Affiliations

  1. Chirurgische Klinik der Universität München, Deutschland

    F. Sebening, S. Hagl, H. Meisner, R. Pichlmayr, P. Schmidt-Habelmann & E. Struck

Authors
  1. F. Sebening
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  2. S. Hagl
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  3. H. Meisner
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  4. R. Pichlmayr
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  5. P. Schmidt-Habelmann
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  6. E. Struck
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Additional information

Herrn Professor Dr. Dr. h. c. R.Zenker zu seinem 65. Geburtstag in Verehrung und Dankbarkeit gewidmet.

Der Deutschen Forschungsgemeinschaft haben wir für die Unterstützung dieser Arbeit zu danken.

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Sebening, F., Hagl, S., Meisner, H. et al. Zur Technik und Physiologie heterotop transplantierter Herzen. Z. Gesamte Exp. Med. 146, 320–328 (1968). https://doi.org/10.1007/BF02043641

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  • DOI: https://doi.org/10.1007/BF02043641

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