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The blood flow in the forearm in patients with cardiac failure

I. The relationship between the cardiac output and the blood flow in the forearm

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Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

In 11 healthy subjects, in 9 patients with cardiac failure in whom the cardiac index was greater than 2.01/min/m2, and in 7 patients in whom the cardiac index was less than 2.01/min/m2, the blood flow of the forearm and the relationship between the cardiac index and the blood flow of the forearm have been studied. In 6 healthy subjects and 8 patients with heart failure the influence of the intraarterial infusion of Pronethalol, and in 6 patients with cardiac failure the intraarterial infusion of atropin on the blood flow of the forearm was studied.

In the group of patients in whom the cardiac index was higher than 2.0 ml/min/m2 the blood flow in the forearm was the same as in the control group, though the cardiac index was decreased. In the group with cardiac index less than 2.0 1/min/m2 there was a decrease of the blood flow of the forearm.

Intraarterial infusion of Pronethalol in healthy subjects was without effect on the circulation of the forearm. In patients with cardiac failure in whom the blood flow through the forearm was higher, pronethalol decreased the forearm circulation. The administration of atropin in patients with heart failure was without effect on the circulation of the forearm.

Zusammenfassung

Bei 11 kardial gesunden Personen, weiters bei 9 kardial dekompensierten Patienten, bei denen der Herzindex größer als 2,0 1/min/m2 war, sowie bei 7 Patienten, bei denen der Herzindex kleiner als 2,0 1/min/m2 war, untersuchten wir die Beziehung zwischen der Durchblutung des Unterarmes und dem Herzindex. Bei 6 kardial gesunden Personen und bei 8 kardial dekompensierten Patienten verfolgten wir den Einfluß einer intraarteriellen Infusion von Pronethalol auf die Durchblutung des Unterarmes. Bei 6 kardial dekompensierten Patienten analysierten wir den Einfluß einer intraarteriellen Infusion von Atropin auf die Durchblutung des Unterarmes.

In der Gruppe der kardial dekompensierten Patienten mit größerem Herzindex als 2,0 1/min/m2 war die Durchblutung des Unterarmes derselbe wie in der Kontrollgruppe. Bei Patienten mit kleinerem Herzindex als 2,0 1/min/m2 fanden wir eine verminderte Durchblutung des Unterarmes.

Eine intraarterielle Infusion von Pronethalol bei gesunden Personen beeinflußte die Zirkulation des Unterarmes nicht. Bei kardial dekompensierten Patienten, bei denen die Durchblutung des Unterarmes erhöht war, bewirkte eine Infusion von Pronethalol eine Verminderung. Die Applikation von Atropin bei herzdekompensierten Patienten war ohne Einfluß auf die Unterarmdurchblutung.

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References

  1. Abramson, D. I., S. M. Fierst, andK. Flachs: Effects of muscular exercise upon the peripheral circulation in patients with valvular heart disease. J. clin. Invest.21, 747 (1942).

    Article  PubMed  CAS  Google Scholar 

  2. Barcroft, H., andH. J. C. Swan: Sympathetic control of human blood vessels. London: Arnold 1953.

    Google Scholar 

  3. Blair, D. A., W. E. Glover, A. D. M. Greenfield, andI. C. Roddie: Excitation of cholinergic vasodilator nerves to human skeletal muscle during emotional stress. J. Physiol. (Lond.)148, 633 (1959).

    CAS  Google Scholar 

  4. Blair, D. A., W. E. Glover, andI. C. Roddie: Vasomotor responses in the human arm during leg exercise. Circulat. Res.9, 264 (1961).

    Google Scholar 

  5. Brod, J., V.Fencl, Z.Hejl, J.Jirka, and M.Ulrych: Muscle blood flow in heart failure. Abstracta IV. Congressus cardiologicus Europaeus, Pragae 1964, p. 47.

  6. Chidsey, C. A., D. C. Harrison, andE. Braunwald: Augmentation of the plasma nor-epinephrine responses to exercise in patients with congestive heart failure. New. Engl. J. Med.267, 650 (1962).

    Article  PubMed  CAS  Google Scholar 

  7. Cohn, A. E., andJ. M. Steele: Unexplained fever in heart failure. J. clin. Invest.13, 853 (1934).

    Article  PubMed  CAS  Google Scholar 

  8. Cooper, K. E., O. G. Edholm, andR. F. Mottram: The blood flow in skin and muscle of the human forearm. J. Physiol. (Lond.)128, 258 (1955).

    CAS  Google Scholar 

  9. Folkow, B.: Autoregulation in muscle and skin. Circulat. Res. Suppl. I.,19 (1964).

  10. Howitt, G., J. Tinker, andE. G. Wade: The effect of pronethalol in mitral stenosis. Clin. Sci.28, 417 (1965).

    PubMed  CAS  Google Scholar 

  11. Kettel, L. J., H. W. Overbeck, R. M. Daugherty, J. P. Lillehei, R. F. Coburn, andF. J. Haddy: Responses of the human upper extremity vascular bed to exercise, cold, levarterenol, angiotensin, hypertension, heart failure, and respiratory tract infection with fever. J. clin. Invest.43, 1561 (1964).

    Article  PubMed  CAS  Google Scholar 

  12. Kuschke, H. J.: Untersuchungen über den Erregungszustand des sympathischen Nervensystems und des Nebennierenmarkes bei kardiovaskulären Erkrankungen. Arch. Kreisl.-Forsch.36, 104 (1961).

    Article  CAS  Google Scholar 

  13. Landt, H., andJ. E. Benjamin: Changes in the content of carbon dioxide in venous blood during rebreathing experiments. Comparison of change in persons with a normal heart and in patients with cardiac disease. Arch. intern. Med.67, 72 (1941).

    CAS  Google Scholar 

  14. Linhart, J., and I.Přerovsky: Praha: Thomayerová sbírka 1958.

  15. Lowe, R. D., andB. F. Robinson: Effect of differential adrenergic blockade on response of forearm blood flow to infused catecholamines. Clin. Sci.26, 81 (1964).

    PubMed  CAS  Google Scholar 

  16. Mason, D. T., andE. Braunwald: Studies on digitalis X. Effect of Ouabain on forearm vascular resistance and venous tone in normal subjects and in patients in heart failure. J. clin. Invest.43, 532 (1964).

    Article  PubMed  CAS  Google Scholar 

  17. McMichael, J., andE. P. Sharpey-Scafer: The action of intravenous digosin in man. Quart. J. Med.13 123 (1944).

    Google Scholar 

  18. Munth, H. A. V., P. N. Wormald J. M. Bishop andK. W. Donald: Further studies of blood flow in the resting arm during leg exercise. Clin. Sci.17 603 (1958).

    Google Scholar 

  19. Pekkarinen, A., E. Iisalo, A. Kasanen B. Laihinen, andB. Thomason: The adrenosympathetic and adrenocortical function in cardiac insufficiency. Amer. J. Cardiol.5 604 (1960).

    Article  PubMed  CAS  Google Scholar 

  20. Rodbard, S.: Evidence that vascular conductance is regulated at the capillary. Hypertension13, 160 (1965).

    Google Scholar 

  21. Roddie, I. C.: andJ. T. Shepherd: The reflex nervous control of human skeletal muscle blood vessels. Clin. Sci.15, 433 (1956).

    PubMed  CAS  Google Scholar 

  22. — — andR. F. Whelan: The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating. J. Physiol. (Lond.)136, 489 (1957).

    CAS  Google Scholar 

  23. — — —: Reflex changes in vasoconstrictor tone in human skeletal muscle in response to stimulation of receptors in the low-pressure area of the intrathoracic vascular bed. J. Physiol. (Lond.)139, 369 (1957).

    CAS  Google Scholar 

  24. Schreiner jr.,B. P., T. Lovejoy, andP. N. Yu: Estimation of cardiac output from precordial dilution curves in patients with cardiopulmonary disease. Circulat. Res.7, 595 (1959).

    PubMed  Google Scholar 

  25. Schweitzer, P., andM. Torma: Oxygen consumption and blood flow in the muscle of the forearm in patients with cardiac failure. Clin. Sci.25 493 (1963).

    PubMed  CAS  Google Scholar 

  26. Scott, R. W.: The total carbonate content of the arterial and venous plasma in patients with chronic heart disease. Proc. Soc. exp. Biol. (N.Y.)17, 19 (1919).

    CAS  Google Scholar 

  27. Sharpey-Schafer, E. P.: Venous tone: effects of reflex changes, humoral agents and exercise. Brit. med. Bull.19, 145 (1963).

    PubMed  CAS  Google Scholar 

  28. Stewart, H. J., W. F. Evans, H. Brown, andJ. R. Gerjuoy: Peripheral blood flow, rectal and skin temperature in congestive heart failure. The effects of rapid digitalisation in this state. Arch. intern. Med.77, 643 (1946).

    Google Scholar 

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Schweitzer, P., Pivoňka, M. & Klvaňová, H. The blood flow in the forearm in patients with cardiac failure. Z. Gesamte Exp. Med. 143, 126–135 (1967). https://doi.org/10.1007/BF02042880

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