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Radiation sterilization of chitosan sealant for vascular prostheses

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Abstract

Chitosan was used as a sealant of knitted polyester vascular grafts. Three sterilization methods for chitosan-coated prostheses were tested: sterilization with ethylene oxide, formaldehyde and irradiation with gamma rays. Radiation sterilization was found to be the most promising of tested methods. The radiation-induced changes in chitosan irradiated in solid state were investigated. Main chain scission was found as the predominant effect of irradiation. Changes in IR and UV spectra were analyzed. Existence of some post-effects was detected. It seems that the observed increase in biocompatibility of chitosan surface caused by irradiation with sterilizing dose (25 kGy) is due to some structural factor connected with a decrease in molecular weight.

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Authors and Affiliations

  1. Institute of Applied Radiation Chemistry, Technical University of Łódź, Wróblewskiego 15, 93-590, Łódź, (Poland)

    J. Rosiak & P. Ulański

  2. Institute of Man Made Fibers, Technical University of Łódź, Zwirki 36, 90-924, Łódź, (Poland)

    M. Kucharska & J. Dutkiewicz

  3. Laboratory of Hemostasis, Institute of Pathology, Medical Academy of Łódź, Narutowicza 96, 91-141, Łódź, (Poland)

    L. Judkiewicz

Authors
  1. J. Rosiak
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  2. P. Ulański
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  3. M. Kucharska
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  4. J. Dutkiewicz
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  5. L. Judkiewicz
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Rosiak, J., Ulański, P., Kucharska, M. et al. Radiation sterilization of chitosan sealant for vascular prostheses. Journal of Radioanalytical and Nuclear Chemistry, Articles 159, 87–96 (1992). https://doi.org/10.1007/BF02041021

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  • DOI: https://doi.org/10.1007/BF02041021

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