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Activation analysis of selenium in cancer research

  • Application of Radioanalytical Techniques to Biological and Biomedical Sciences
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Abstract

The method described in a previous work to separate trace amounts of selenium in organic samples without using a carrier, based on the adsorption on active carbon filters of the complex formed with ammonium pyrrolidindithiocarbamate (APDC) at pH 1.5–2, has been applied to urine samples from 15 females patients suffering from cervical uterine cancer. With this type of sample the method reaches a maximum sensitivity (few ppb) with a good statistical variation (±12%). Since the highest concentration of selenium in human tissues is found in the kidney, and the elimination of this element is mainly by the urine, the method seems to be a powerful tool in the research about the human metabolism of selenium. This paper shows a possible relation of selenium concentration in human urine and the evolution time of cervical uterine cancer, in spite of limits imposed by the statistical error plus the inhomogeneity of the sample.

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Authors and Affiliations

  1. Faculty of Chemistry, National University of Mexico, Bldg. D. C.U., 04510, Mexico City, Mexico

    M. Navarrete, L. Cabrera & T. Martinez

  2. Laboratoire Pierre Süe, CEN-Saclay, 91191, Gif-sur-Yvette Cedex, France

    G. Revel

  3. Service du Réacteur Universitaire de Strasbourg, 17 rue Becquerel, 67035, Strasbourg Cedex, France

    J. P. Meyer

Authors
  1. M. Navarrete
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  2. L. Cabrera
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  3. T. Martinez
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  4. G. Revel
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  5. J. P. Meyer
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Navarrete, M., Cabrera, L., Martinez, T. et al. Activation analysis of selenium in cancer research. Journal of Radioanalytical and Nuclear Chemistry, Articles 195, 91–95 (1995). https://doi.org/10.1007/BF02036477

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  • DOI: https://doi.org/10.1007/BF02036477

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