Abstract
Copper-67 is a radioisotope with significant potential for diagnostic and therapeutic applications in nuclear medicine. Despite its promise,67Cu has failed to make an impact in clinical nuclear medicine, primarily because it is available sporadically, and in limited quantities. Common methods of production rely on high energy proton irradiation of natural zinc targets or on induced reactions using high energy neutrons at nuclear reactors. We have evaluated alternative production methods that could provide year-round adequate supply of this isotope. Using a low energy accelerator, we have studied the production of67Cu by proton reactions on enriched70Zn. Our results indicate that it is possible to produce useful quantities of67Cu from the irradiation of enriched70Zn with protons that have energies of less than 20 MeV. Production rates are higher than currently used methods at high energy accelerators or reactors. This isotope can be made available throughout the year as a result of this research.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. BROWNE, R. B. FIRESTONE, and V. S. SHIRLEY, Table of Radioactive Isotopes, John Wiley and Sons, New York, USA, (1986)
G. DE NARDO, S. DE NARDO, D. KUKUIS, H. DIRIL, C. SUEY, and C. MEARES, Int. J. Instrum. Part B, Nucl. Med. Biol. 18, (1992), 633
D. A. COLE, J. A. MERCER-SMITH, S. A. SCHREYER, J. K. NORMAN, and D. K. LAVALLEE, Nuc. Med. BIOl. 17, (1990), 457
D. A. COLE, D. C. MOODY, L. E. ELLINWOOD, M. G. KLEIN, J. A. MERCER-SMITH, A. BRUMBAUGH, R. O. EIKLEBERRY, D. LEWIS, G. SACCOMANNO, J. J. BECKTEL, and D. K. LAVALLEE, New Trends in Radiopharmaceutical Synthesis, Quality Assurance and Regulatory Control, (A. Emran, ed.) Plenum Press, New York, (1991), 109
J. A. MERCER-SMITH, J. C. ROBERTS, S. D. FIGARD, and D. K. LAVALLEE, Vol. 1 of Targeted Diagnosis and Therapy Series(J. T. Rodwell, ed.), Marcel Dekker, New York, (1988), 317
J. C. ROBERTS, S. D. FIGARD, J. A. MERCER-SMITH, Z. V. SVITRA, W. L. ANDERSON, and D. K. LAVALLEE, J. Immunol. Meth., 105, (1987), 153
S. V. DESHPANDE, S. J. DE NARDO, C. F. MEARES, M. J. McCALL, G. P. ADAMS, M. K. MOI, and G. L. DE NARDO, J. Nucl. Med. 29, (1988), 217
S. MIRZADEH, F. F. KNAPP Jr., Radiochimica Acta, 57, (1992), 193
M. BLANN, J. BISPLINGHOFF, Code ALICE/Livermore 82. Lawrence Livermore National Laboratory-Internal Report UCID-19614, November 5, 1982.
J. F. ZIEGLER, J. P. BIERSACK, and V. LITTMARK, The Stopping and Range of Ions in Solids, Pergamon Press, Inc., New York, USA, (1985)
V. N. LEVKOVSKII, Activation Cross Section Nuclides of Average Masses(A=40-100) by Protons and Alpha-Particles with Average Energies (E=10-50 MeV), Moscow, Russia, (1991)
M. BARBIER, Induced Radioactivity, North Holland Publishing Co., Amsterdam-London, (1969)
S. MEGHIR, and L. YAFFE, Ph.D. Thesis, McGill University, Montreal, Quebec, Canada, (1962)
K. A. KRAUS, and F. NELSON, Proceedings of the International Conference on the Peaceful Uses of Atomic Energy, 1955, United Nations Vol. 7, (1956), 113
K. KOLSKY, p.c., Brookhaven National Laboratory, (1994)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
sr Jamriska, D.J., Taylor, W.A., Ott, M.A. et al. Activation rates and chemical recovery of67Cu produced with low energy proton irradiation of enriched70Zn targets. Journal of Radioanalytical and Nuclear Chemistry, Articles 195, 263–270 (1995). https://doi.org/10.1007/BF02035965
Issue Date:
DOI: https://doi.org/10.1007/BF02035965