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Autophagy in mouse hepatocytes induced by lysine acetylsalicylate

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Summary

I.v. administration of lysine acetylsalicylate inces autophagy in mouse liver cells. Single and multiple membrane-bounded vacuoles were found. The latter seems to be an unusual morphological form of the sequestration process. These findings could express a transitory sublethal liver cell injury induced by the drug.

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References

  1. H. Hubner and H. P. Rhor, Beitr. path. Anat.139, 362 (1969).

    CAS  Google Scholar 

  2. E. R. Bullock, V. D. Delaney, B. C. Sawyer and T. F. Slater, Biochem. Pharmac.19, 245 (1973).

    Article  Google Scholar 

  3. U. N. Riede, Experientia29, 184 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. W. E. Seaman, K. G. Ishak and P. H. Plotz, Ann. intern. Med.80, 1 (1974).

    Article  CAS  PubMed  Google Scholar 

  5. J. D. Wolfe, A. L. Metzeger and R. G. Goldstein, Ann. intern. Med.80, 71 (1974).

    Article  Google Scholar 

  6. D. L. Goldenberg, Ann. intern. Med.80, 773 (1974).

    Article  CAS  PubMed  Google Scholar 

  7. E. Garber and R. M. Graig, Ann. intern. Med.82, 592 (1975).

    Article  CAS  PubMed  Google Scholar 

  8. T. C. Iancu and E. Elian, Am. J. clin. Path.66, 570 (1976).

    Article  CAS  PubMed  Google Scholar 

  9. H. J. Zimmerman, Ann. intern. Med.80, 103 (1974).

    Article  CAS  PubMed  Google Scholar 

  10. C. De Duve and R. Wattiaux, A. Rev. Physiol.28, 435 (1966).

    Article  Google Scholar 

  11. M. E. Fedorko, J. G. Hirsch and Z. A. Cohn, J. Cell Biol.38, 392 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. A. Arstilla and B. F. Trump, Am. J. Path.53, 687 (1968).

    Google Scholar 

  13. J. L. E. Ericsson, Lysosomes, in: Biology and Pathology, vol. 2, p. 345. Ed. J. T. Dingle and H. B. Fell. North Holland Publishing Co., Amsterdam 1969.

    Google Scholar 

  14. Z. Hruban, A. Slevers and E. Hopkine, Lab. Invest.27, 62 (1972).

    CAS  PubMed  Google Scholar 

  15. F. N. Ghadially, Ultrastructural Pathology of the Cell, p. 300. Butterworths, London 1975.

    Google Scholar 

  16. J. O. Soares, A. P. Aguas and J. F. Moura-Nunes, Am. J. clin. Path.68, 629 (1977).

    Article  CAS  PubMed  Google Scholar 

  17. T. C. Iancu and E. Elian, Am. J. clin. Path.68, 630 (1977).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Unidade de Microscopia Electrónica, Faculdade de Medicina de Lisboa, Laboratório de Virologia, Instituto Português de Oncologia, Lisboa, Portugal

    A. P. aguas, J. O. Soares & J. F. Moura Nunes

Authors
  1. A. P. aguas
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  2. J. O. Soares
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  3. J. F. Moura Nunes
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Additional information

Acknowledgments. The authors are indebted to Mrs M. T. Correia and to Mrs M. E. Pereira for technical assistance.

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aguas, A.P., Soares, J.O. & Moura Nunes, J.F. Autophagy in mouse hepatocytes induced by lysine acetylsalicylate. Experientia 34, 1618–1619 (1978). https://doi.org/10.1007/BF02034711

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