Summary
The influences of dilution, storage and pH on the distribution of 99m-technetium methylene diphosphonate (99m-Tc-MDP) in bone and various soft tissues have been investigated in the rat. The results show a marked departure from normality when large dilution factors and very acidic or basic preparations are used.
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References
R.A.A. Khan and B. Sheasby, J. clin. Pharm1, 163 (1976).
G. Subramanian, J.G. McAfee, R.J. Blair, F.A. Kallfelz and F.D. Thomas, J. nucl. Med.16, 744 (1975).
R.A.A. Khan, J.K. Best and J.P. Lavender, Br. J. Radiol.51, 51 (1978).
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Khan, R.A.A. Factors influencing the distribution of 99m-technetium methylene diphosphonate in bone and soft tissues. Experientia 34, 1598–1600 (1978). https://doi.org/10.1007/BF02034698
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DOI: https://doi.org/10.1007/BF02034698