Summary
In a patient with Behçet's syndrome the finding of five times the normal level of serum transaminase accompanied by weakness may be correlated to the syndrome itself. We performed needle biopsy of the liver in our patient which showed piecemeal necrosis and portal lympho-monocytic infiltration extending into the lobule. It is interesting that HLA B5 and B27 antigens were present. Simultaneous occurrence of chronic active hepatitis and Behçet's syndrome may imply the same autoimmune pathogenesis, as we suggest in this work.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Behçet, H. Ueber rezidvierende Aphtöse, durch ein virus verursachte Geschwüre am Mund, am Auge und an den Genitalen. Dermatol Wochenschr, 1937, 105, 1152–1157.
Mason, R.M., Barnes, C.G. Behçet's syndrome with arthritis. Ann Rheum Dis, 1969, 28, 95–103.
Davies, J.D. Behçet's syndrome with haemophtysis and pulmonary lesions. J Pathol, 1973, 109, 351–356.
Hills, E.A. Behçet's syndrome with aortic aneurysms. Br Med J, 1967, 4, 152–154.
Hamza, M., Ben Maiz, H., Ben Hayed, H. Maladie de Behçet avec maniféstation rénale. A propos d'un cas suivi pendant six ans. Sem Hôp Paris, 1980, 56 (21–24), 1081–1083.
Herreman, G., Beaufils, H., Godeau, P. et al. Behçet's syndrome and renal involvement: A histological and immunofluorescent study of eleven renal biopsies. Am J Med Sci, 1982, 284 (1), 10–17.
Oshima, Y., Shimizu, T., Yokhari, R. et al. Clinical studies on Behçet's syndrome. Ann Rheum Dis, 1963, 22, 36–45.
Reiner, G., Djawari, D. Lymphocytotoxicity for oral epithelial cells in Behçet's disease. A case report. Dermatologica, 1982, 164, 82–89.
Nazzaro, P. Cutaneous manifestations of Behçet's disease. In: Behçet's Disease. Editors: M. Monacelli, P. Nazzaro. S Karger, Basel and New York, 1966, pp. 15–41.
Chajek, T., Fainaru, M. Behçet's disease. Report of 41 cases and a review of the literature. Medicine, 1975, 54, 179–196.
Ohno, S., Aoki, K., Sugiura, S. et al. HLA B5 and Behçet's disease. Lancet, 1973, 21383-1384.
Yazici, H., Akokan, G., Yalcin, B. et al. The high prevalence of HLA B5 in Behçet's disease. Clin Exp Immunol, 1977, 30, 259–261.
Chamberlain, M.A. Behçet's syndrome in 32 patients in Yorkshire. Ann Rheum Dis, 1977, 36, 491–499.
Kansu, E., Ozer, F.L., Akalin, E. et al. Behçet's syndrome with obstruction of the venae cavae. A report of 7 cases. Quart J Med, 1972, 41, 151–168.
Valleteau De Moulliac, M., Morin, M., Graveleau, J. et al. A propos d'un cas d'association de syndrome de Budd-Chiari et de syndrome de Behçet. Sem Hôp Paris, 1974, 50, 2679–2683.
Barret, L., Peyron, F., Gaillat, J. et al. Syndrome de Budd-Chiari au cours de la maladie de Behçet. Lyon Médical, 1982, 247, 349–352.
Webb, J., Whaley, K., Mac Sween, R.N.M. et al. Liver disease in rheumatoid arthritis and Sjogren's syndrome. Ann Rheum Dis, 1975, 34, 70.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Manna, R., Ghirlanda, G., Bochicchio, G.B. et al. Chronic active hepatitis and Behçet's syndrome. Clin Rheumatol 4, 93–96 (1985). https://doi.org/10.1007/BF02032326
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02032326