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Fatal pneumococcal epiglottitis in lupus overlap syndrome

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Summary

A 35-year-old woman with a six-year history of polymyositis, having developed a vasculitic skin rash in the first trimester of her first pregnancy and biopsy-proven lupus glomerulonephritis during the third trimester is described. Investigations performed one month post-partum revealed high DNA binding, the presence of RNP antibodies, a serum CH50 of 0% and a serum C2 of 1%. Despite marked clinical and serological improvement and the reduction of her prednisolone dose to 5 mgs./day, she died at one-year post-partum of acute pneumococcal epiglottitis.

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Authors and Affiliations

  1. Department of Rheumatology, Whittington Hospital, London

    D. A. Isenberg

  2. National Heart Hospital, Westmoreland Street, W1M 8BA, London, UK

    D. P. Lipkin

  3. The Department of Experimental Pathology, St Mary's Hospital, London

    J. F. Mowbray

  4. Department of Histopathology, Royal Marsden Hospital, London

    C. Fisher

  5. Department of Cardiology, Whittington Hospital, London

    R. Davies

Authors
  1. D. A. Isenberg
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  2. D. P. Lipkin
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  3. J. F. Mowbray
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  4. C. Fisher
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  5. R. Davies
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Isenberg, D.A., Lipkin, D.P., Mowbray, J.F. et al. Fatal pneumococcal epiglottitis in lupus overlap syndrome. Clin Rheumatol 3, 529–532 (1984). https://doi.org/10.1007/BF02031277

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  • DOI: https://doi.org/10.1007/BF02031277

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