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Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig

  • Pulmonary Research Group Meeting On Animal Models of Airway Hyperreactivity and Late-Phase Responses
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Abstract

Described is a guinea pig model of allergic asthma, in which animals are sensitized by intraperitoneal injections of ovalbumin complexed with aluminum hydroxide to elicit an IgE response. Aerosol exposure to ovalbumin induces acute bronchoconstriction and nonspecific airways hyperreactivity, evaluated by intravenous challenges of histamine or acetylcholine. This model mimics the hallmark features of human asthma, is induced by respired allergen and is pharmacologically modulated by prophylactic drugs (methyl prednisolone, ketotifen, theophylline) and the competitive PAF receptor antagonist SDZ 264-412.

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Author notes

  1. A. M. Havill

    Present address: Amgen Inc., 91320-1789, Thousand Oaks, CA, USA

Authors and Affiliations

  1. Mediators and Biomolecular Therapy, Monoclonal Antibody Department, Sandoz Research Institute, 07936, East Hanover, NJ, USA

    D. A. Handley, J. J. DeLeo & A. M. Havill

Authors
  1. D. A. Handley
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  2. J. J. DeLeo
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  3. A. M. Havill
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Handley, D.A., DeLeo, J.J. & Havill, A.M. Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig. Agents and Actions 37, 201–203 (1992). https://doi.org/10.1007/BF02028109

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  • DOI: https://doi.org/10.1007/BF02028109

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