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In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes

  • Bone and Cartilage
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Abstract

Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1β (rhIL-1β) in rabbit articular chondrocytes were studiedin vitro. The rhIL-1β-induced PGE2 production was dose-dependently inhibited by HA. HA with the highest molecular weight (M r=2.0×106) exhibited an inhibitory effect that was statistically more significant than the same polymer of lower molecular weights (M r=1.0×106, 0.5×106). This effect was observed in both young and adult rabbit articular chondrocytes. Since PGE2 has been implicated as a mediator of inflammatory joint diseases, our observations suggest that HA may elicit an anti-inflammatory effect by inhibiting PGE2 production.

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Authors and Affiliations

  1. Division of Biochemical Pharmacology, Research Laboratories, Maruho Co., Ltd., 1-8-23 Oyodo Naka, Kita-ku, 531, Osaka, Japan

    M. Akatsuka, Y. Yamamoto, K. Tobetto, T. Yasui & T. Ando

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  1. M. Akatsuka
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  2. Y. Yamamoto
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  3. K. Tobetto
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  4. T. Yasui
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  5. T. Ando
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Akatsuka, M., Yamamoto, Y., Tobetto, K. et al. In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes. Agents and Actions 38 (Suppl 1), 122–125 (1993). https://doi.org/10.1007/BF02027223

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  • DOI: https://doi.org/10.1007/BF02027223

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