Abstract
A case-control study was conducted to examine the association of beta-haemolytic non-group A streptococci and pharyngitis in a paediatric population (n=502). No association could be found between disease and traditional Lancefield groups B, C, F, or G. When the analysis included the clustering of genetically related subgroups from different Lancefield groups, an association was evident for moderate and heavy quantitations of beta-haemolytic “large colony” group C and G streptococci (Streptococcus equisimilis and human biotypes of large colony group G streptococci) (p=0.021). This study further defines a subset of the beta-haemolytic non-group A streptococci that merit recognition by both the laboratory and physician.
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Abbreviations
- BHNAS:
-
beta haemolytic non-group A streptococci
- VP:
-
Voges-Proskauer test
References
Barnham M, Thornton TJ, Lange K (1983) Nephritis caused byStreptococcus zooepidemicus (Lancefield group C). Lancet I: 945–947
Barnham M, Cole G, Efstratiou A, Tagg JR, Skjold SA (1987) Characterization ofStreptococcus zooepidemicus (Lancefield group C) from human and selected animal infections. Epidemiol Inf 98: 171–182
Benjamin JT, Perriello VA Jr (1976) Pharyngitis due to group C hemolytic streptococci in children. J Pediatr 89: 254–256
Berger PC, Elford RW, Yeo M, Cimolai N, Anand CM (1989) Pharyngitis 1987: a survey of physicians' attitudes and practices in southern Alberta. Can J Public Health 80: 38–41
Breese BB, Disney FA, Talpey WB, Green JL (1970) Betahemolytic streptococcal pharyngitis: the clinical and epidemiologic importance of the number of organisms found in cultures. Am J Dis Child 119: 18–26
Cimolai N, Elford RW, Bryan L, Anand C, Berger P (1988) Do the beta-hemolytic non-group A streptococci cause pharyngitis? Rev Infect Dis 10: 587–601
Cimolai N, MacCulloch L, Damm S (1990) The epidemiology of beta-hemolytic non-group A streptococci isolated from the throats of children over a one-year period. Epidemiol Inf 104: 119–126
Clark RB, Berrafati JF, Janda JM, Bottone EJ (1984) Biotyping and exoenzyme profiling as an aid in the differentiation of human from bovine group G streptococci. J Clin Microbiol 20: 706–710
Cohen D, Ferne M, Rouach T, Bergner-Rabinowitz S (1987) Food-borne outbreak of group G streptococcal sore throat in an Israeli military base. Epidemiol Inf 99: 249–255
Devriese LA, Hommez J, Kilpper-Balz R, Schleifer KH (1986)Streptococcus canis sp. nov.: a species of group G streptococci from animals. Int J System Bacteriol 36: 422–425
Duca E, Teodorovici G, Radu C, Vita A, Talasman-Niculescu P, Bernescu E, Feldi C, Rosca V (1969) A new nephritogenic streptococcus. J Hyg 67: 691–698
Edwards AT, Roulson M, Ironside MJ (1988) A milk-borne outbreak of serious infection due toStreptococcus zooepidemicus (Lancefield group C). Epidemiol Inf 101: 43–51
Efstratiou A (1989) Outbreaks of human infection caused by pyogenic streptococci of Lancefield groups C and G. J Med Microbiol 29: 207–219
Efstratiou A, Teare EL, McGhie D, Colman G (1988) The presence of M proteins in outbreak strains ofStreptococcus equisimilis T-type 204. J Infect 19: 105–111
Ezaki T, Facklam R, Takeuchi N, Yabuuchi E (1986) Genetic relatedness between the type strain ofStreptococcus anginosus and minute-colony-forming beta-hemolytic streptococci carrying different Lancefield grouping antigens. Int J System Bacteriol 36: 345–347
Facklam RR, Carey RB (1985) Streptococci and aerococci. In: Lennette EH, Balows A, Hausler WJ Jr, Shadomy HJ (eds) Manual of clinical microbiology, 4th edn. Washington, DC: American Society for Microbiology, Washington, pp 154–175
Farrow JAE, Collins MD (1984) Taxonomic studies on streptococci of serological groups C, G, and L and possibly related taxa. System Appl Microbiol 5: 483–493
Gerber MA, Randolph MF, Chanatry J, Wright LL, DeMeo KK, Anderson LR (1986) Antigen detection test for streptococcal pharyngitis: evaluation of sensitivity with respect to true infections. J Pediatr 108: 654–658
Hamrick HJ (1986) The throat culture reconsidered (editorial). J Pediatr 108: 416–417
Hayden GF, Murphy TF, Hendley JD (1989) Non-group A streptococci in the pharynx: pathogens or innocent bystanders? Am J Dis Child 143: 794–797
Hill HR, Caldwell GG, Wilson E, Hager D, Zimmerman RA (1969) Epidemic of pharyngitis due to streptococci of Lancefield group G. Lancet II: 371–374
Kaplan EL, Top FH Jr, Dudding BA, Wannamaker LW (1971) Diagnosis of streptococcal pharyngitis: differentiation of active infection from the carrier state in the symptomatic child. J Infect Dis 123: 490–501
Kaplan E, Nussbaum M, Shenker IR, Munday M, Isenberg HD (1977) Group C hemolytic streptococcal pharyngitis (letter). J Pediatr 90: 327–328
Kilpper-Balz R, Schleifer KH (1984) Nucleic acid hybridization and cell wall composition studies of pyogenic streptococci. FEMS Microbiol Lett 24: 355–364
Kilpper-Balz R, Williams BL, Lütticken R, Schleifer KH (1984) Relatedness of “Streptococcus milleri” withStreptococcus anginosus andStreptococcus constellatus. System Appl Microbiol 5: 494–500
Kohler W, Cederberg A (1976) AStreptococcus zooepidemicus (group C streptococci) as a cause of human infection. Scand J Infect Dis 8: 217–218
Lawrence J, Yajko DM, Hadley WK (1985) Incidence and characterization of beta-hemolyticStreptococcus milleri and differentiation fromS. pyogenes (group A),S. equisimilis (group C), and large-colony group G streptococci. J Clin Microbiol 22: 772–777
McCue JD (1982) Group G streptococcal pharyngitis: analysis of an outbreak at a college. JAMA 248: 1333–1336
Meier FA, Centor RM, Graham L, Dalton MP (1990) Clinical and microbiological evidence for endemic pharyngitis among adults due to Group C streptococci. Arch Intern Med 150: 825–829
Rudensky B, Isacsohn M (1989) Beta-hemolytic group C streptococci and pharyngitis (letter). Rev Infect Dis 11: 668
Stillerman M, Bernstein SH (1961) Streptococcal pharyngitis: evaluation of clinical syndromes in diagnosis. Am J Dis Child 101: 476–489
Stryker WS, Fraser DW, Facklam RR (1982) Foodborne outbreak of group G streptococcal pharyngitis. Am J Epidemiol 116: 533–540
Whiley RA, Hardie JM (1989) DNA-DNA hybridization studies and phenotypic characteristics of strains within theStreptococcus milleri group. J Gen Microbiol 135: 2623–2633
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Cimolai, N., Morrison, B.J., MacCulloch, L. et al. Beta-haemolytic non-group A streptococci and pharyngitis: A case-control study. Eur J Pediatr 150, 776–779 (1991). https://doi.org/10.1007/BF02026709
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DOI: https://doi.org/10.1007/BF02026709