Abstract
Part II demonstrates the results of MRI follow up studies of 23 children with leukemia. Differentiation between leukemic cells and normal hematopoesis by MRI is impossible. The state of disease can only be determined together with bone marrow biopsy. Clinical remission precedes the normalization of bone marrow signal by weeks. In non-responders, however, cytological findings and MRI findings seem to correlate at the same time. During therapy, areas of osteonecrosis may develop. They do not necessarily contradict continuing complete remission. But this does not affect the prognosis and complete remission is still a possibility. Diagnosis of relapse by MRI is only possible in correlation with studies during the different states of disease especially at clinical remission.
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Moore SG, Gooding CA, Brasch RC, Ehman RL, Ringertz HG, Ablin AR, Matthay KK, Zoger S (1986) Bone marrow in children with acute lymphocytic leukemia: MR relaxation times1. Radiology 160: 237
Nyman R, Rehn S, Glimelius B, Hagberg H, Hemmingsson A, Jung B, Simonsson B, Sundström C (1987) Magnetic resonance imaging in diffuse malignant bone marrow diseases. Acta Radiol [Diagn] (Stockh) 28: 199
Thomsen C, Sørensen PG, Karle H, Christoffersen P, Henriksen O (1987) Prolongated bone marrow T1-relaxation in acute leukaemia. In vivo tissue characterization by magnetic resonance imaging. Magn Reson Imaging 5: 251
Kangarloo H, Dietrich RB, Taira RT, Gold RH, Lenarsky C, Boechat MI, Feig SA, Salusky I (1986) MR imaging of bone marrow in children. J Comput Assist Tomogr 10: 205
Pieters R, van Brenk AI, Veerman AJP, Taets van Amerongen AHM, van Zanten TEG, Golding RP (1987) Bone marrow magnetic resonance studies in childhood leukemia. Evaluation of osteonecrosis. Cancer 60: 2994
Riehm H (1986) Therapiestudie ALL/NHL-BFM-86. Multizentrische Therapiestudie der BFM-Gruppe zur Behandlung der akuten lymphoblastischen Leukämie und der Non-Hodgkin-Lymphome im Kindes- und Jugendalter. Kinderklinik der MHH, Konstanty-Gutschow-Str. 8, D-3000 Hannover 61
Schellong G (1987) Therapiestudie AML-BFM-87 für die akute myeloische Leukämie bei Kindern. Universitäts-Kinderklinik, Albert-Schweitzer-Str. 33, D-4400 Münster
Bohndorf K, Benz-Bohm G, Gross-Fengels W, Berthold F (1990) MRI of the knee region in leukemic children. Part I. Initial pattern in patients with untreated disease. Pediatr Radiol 20: 179
Ranade SS, Shah S, Advani SH, Kasturi SR (1977) Pulsed nuclear magnetic resonance studies of human bone marrow. Physiol Chem Phys Med NMR 9: 297
Kricun ME (1985) Red-yellow marrow conversion: its effect on the location of some solitary bone lesions. Skeletal Radiol 14: 10
Irving MG, Brooks WM, Brereton IM, Galloway GJ, Field J, Bell JR, Harris MG, Baddeley H, Doddrell DM (1987) Use of high resolution in vivo volume selected1H-magnetic resonance spectroscopy to investigate leukemia in humans. 6th Annual Meeting of SMRM, Book of abstracts, vol. 1. New York, p 152
Porter BA, Shields AF, Olson DO (1986) Magnetic resonance imaging of bone marrow disorders. Radiol Clin North Am 24: 269
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Dedicated to Professor Dr. E. Willich on the occasion of his 70th birthday
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Benz-Bohm, G., Gross-Fengels, W., Bohndorf, K. et al. MRI of the knee region in leukemic children. Pediatr Radiol 20, 272–276 (1990). https://doi.org/10.1007/BF02019665
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DOI: https://doi.org/10.1007/BF02019665