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Renal dysplasia in infants: Apperance on99mTc DMSA scintigraphy

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Abstract

Infantile renal dysplasias, including multicystic dysplastic kidneys (MCDK), are reported rarely to accumulate radiopharmaceuticals on renal scintigraphy.99mTc DMSA is a highly sensitive tracer for detecting functioning renal cortical tissue and may be more suited to studying renal dysplasia than99mTc DTPA. We reviewed the ultrasound studies and99mTc DMSA scintigrams of 42 infants (age range 1–12 months) with known or suspected MCDK. Overall, uptake on99mTc DMSA scintigraphy was evident in 6/41 (15%) dysplastic kidneys. Of the 18 patients who underwent nephrectomy, histopathological examination revealed that uptake correlated closely with the presence of mature renal cortical tissue in the affected kidney. Our study shows that a small, but significant number of MCDK will show low-grade uptake on DMSA scintigraphy. This finding may be relevant given the reliance placed on renal scintigraphy in planning treatment for infants with suspected MCDK, particularly with the increasing trend for the non-operative management of this condition.

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Authors and Affiliations

  1. Department of Radiology, Division of Nuclear Medicine, The Children's Hospital and Harvard Medical School, Boston, MA, USA

    P. J. Roach, H. J. Paltiel, R. J. Tello, R. T. Davis & S. T. Treves

  2. Department of Pathology, The Children's Hospital and Harvard Medical School, Boston, MA, USA

    A. Perez-Atayde

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  1. P. J. Roach
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  2. H. J. Paltiel
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  3. A. Perez-Atayde
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  4. R. J. Tello
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  5. R. T. Davis
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  6. S. T. Treves
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Roach, P.J., Paltiel, H.J., Perez-Atayde, A. et al. Renal dysplasia in infants: Apperance on99mTc DMSA scintigraphy. Pediatr Radiol 25, 472–475 (1995). https://doi.org/10.1007/BF02019071

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  • DOI: https://doi.org/10.1007/BF02019071

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