Skip to main content
SpringerLink
Log in

Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria andChlamydia trachomatis

  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

The in vitro activity of A-56268 (TE-031) was determined and compared with that of 13 antibiotics against 401 gram-positive and gram-negative bacteria and 11 strains of Chlamydia trachomatis.A-56268 was very active against methicillin-susceptible Staphylococcus aureus and Neisseria gonorrhoeae,and was among the most active of the agents tested against Listeria monocytogenes,streptococci and Chlamydia trachomatis.It was moderately active against Haemophilus spp.,Vibrio spp.,Campylobacter jejuni and Campylobacter fetus subsp. fetus.It was inactive against enterococci, methicillin-resistant Staphylococcus aureus,Staphylococcus epidermidis, Campylobacter coli, Salmonella spp.,Shigella spp. and Yersinia enterocolitica.A-56268 was not consistently bactericidal or more active than erythromycin for any organism except Chlamydia trachomatis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Thornsberry, C., McDougal, L. K.: Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. Journal of Clinical Microbiology 1983, 18: 1084–1091.

    PubMed  Google Scholar 

  2. National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Volume 5. Villanova, PA, 1986, p. 579–616.

  3. Benson, C. A., Walton, F. E., Trenholme, G. M.: Antibacterial activity of Ro 17-2301 and other antimicrobial agents against cefotaxime-resistant aerobic gram-negative bacilli. Antimicrobial Agents and Chemotherapy 1986, 29: 155–157.

    PubMed  Google Scholar 

  4. Segreti, J., Kessler, H. A., Kapell, K. S., Trenholme, G. M.: In vitro activity of A-56268 (TE-031) and four other antimicrobial agents againstChlamydia trachomatis. Antimicrobial Agents and Chemotherapy 1987, 31: 100–101.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Infectious Disease, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, 1753 West Congress Parkway, 60612, Chicago, Illinois, USA

    C. Benson, J. Segreti, H. Kessler, D. Mines, L. Goodman, R. Kaplan & G. Trenholme

Authors
  1. C. Benson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Segreti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Kessler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Mines
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Goodman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Kaplan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Trenholme
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benson, C., Segreti, J., Kessler, H. et al. Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria andChlamydia trachomatis . Eur. J, Clin. Microbiol. 6, 173–178 (1987). https://doi.org/10.1007/BF02018203

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02018203

Keywords

Search

Navigation