Skip to main content
SpringerLink
Log in

Lectin-Mediated bacterial adhesion to human tissue

  • Notes
  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

In vitro experiments with frozen sections of human lung and kidney demonstrated that adhesion of Streptococcus pneumoniae Pn 629 Type 14 and Pseudomonas aeruginosa ATCC 27853 to human cells was mediated by bacterial lectins (adhesins) with N-acetyl-D-glucosamine/D-galactose or N-acetyl-neuraminic acid specificity. Blocking of the lectin binding sites on bacterial surfaces with competitive carbohydrates completely prevented the bacterial adherence,whereas non-specific carbohydrates (D-mannose, D-xylose) did not inhibit adherence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hazlett, L. D., Moon, M., Beck, R. S.: In vivo identification of sialic acid as the ocular receptor forPseudomonas aeruginosa. Infection and Immunity 1986, 51: 687–689.

    PubMed  Google Scholar 

  2. Sharon, N.: Lectin-like bacterial adherence to animal cells. In: Baedecker, E. C. (ed.): Attachment of organisms to the gut mucosa. Volume 1. CRC Press, Boca Raton/FA, USA, 1984, p. 129–147.

    Google Scholar 

  3. Beuth, J., Ko, H. L., Schroten, H., Sölter, J., Uhlenbruck, G., Pulverer, G.: Lectin mediated adhesion ofStreptococcus pneumoniae and its specific inhibition in vitro and in vivo. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene 1987, 265: 160–168.

    Google Scholar 

  4. Sharon, N.: Bacterial lectins. In: Liemer, E., Sharon, N., Goldstein, I. J. (ed.): The lectins. Academic Press, London, 1986, p. 494–522.

    Google Scholar 

  5. Wadström, T., Trust, T. J., Brooks, D. E.: Bacterial surface lectins. In: Bog-Hansen, T. C., Spengler, G. A. (ed.): Lectins. Volume 3. Walter de Gruyter, Berlin, 1983, p. 479–494.

    Google Scholar 

  6. Gilboa-Garber, N.: Lectins ofPseudomonas aeruginosa: properties, biological effects and applications. In: Mirelman, D. (ed.): Microbial lectins and agglutinins. John Wiley and Sons, New York, 1986, p. 255–270.

    Google Scholar 

  7. Ramphal, R., Pier, G.: Role ofPseudomonas aeruginosa mucoid exopolysaccharide in adherence to trachial cells. Infection and Immunity 1985, 47: 1–4.

    PubMed  Google Scholar 

  8. Netland, P. A., Zetter, B. R.: Organ-specific adhesion of metastatic tumor cells in vitro. Science, Washington, DC, 1984, 224: 1113–1115.

    Google Scholar 

  9. Uhlenbruck, G.: Bacterial lectins: mediators of adhesion. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene 1987, 263: 497–508.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Hygiene, University of Cologne, Goldenfelsstr. 19-21, 5000, Cologne 41, FRG

    J. Beuth, H. L. Ko & G. Pulverer

  2. Department of Immunobiology, Medical University Clinic 1, 5000, Cologne 41, FRG

    G. Uhlenbruck

Authors
  1. J. Beuth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. L. Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Uhlenbruck
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Pulverer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Beuth, J., Ko, H.L., Uhlenbruck, G. et al. Lectin-Mediated bacterial adhesion to human tissue. Eur. J, Clin. Microbiol. 6, 591–593 (1987). https://doi.org/10.1007/BF02014258

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02014258

Keywords

Search

Navigation