Summary
There is a significant transient increase in the number of osteoclasts in intact bone after bleedings and fractures in rats. This rise in the osteoclast population might be due to an increased parathyroid activity released by the trauma, but other factors may be involved. Both bleeding and fractures in rats are followed by hypercalcemia.
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References
Dietrich, J.W., Raisz, L.G.: Prostaglandin in calcium and bone metabolism. Clin. Orthrop.111, 228–237 (1975)
Hancox, N.: Biochemistry and Physiology of Bone. Chapter 3,pp. 45–67. New York: Academic Press 1972
Horton, J.E., Raisz, L.G., Simmons, H.A., Oppenheim, J.J., Mergenhagen, S.E.: Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science177, 793–795 (1972)
Hulth, A., Johnell, O.: Cell proliferation in the bone marrow and thymus following fractures in rats. Clin. Orthop.120, 260–263 (1976a)
Hulth, A., Johnell, P.: Cell proliferation in the bone marrow and thymus following partial bone marrow aspiration. Experientia (Basel)32, 1577–1578 (1976b)
Hulth, A., Johnell, O.: Increased osteoclasia after an antigenic challenge in rats. To be published. (1977)
Johnell, O.: Cell proliferation in the bone marrow and thymus following soft tissue damage. Acta orthop. scand. (in press 1977)
Pearse, A.G.E.: Histochemistry: Theoretical and applied, 2nd ed. London: Churchill 1960
Perris, A.D., Whitfield, J.F.: Calcium and the control of mitosis in the mammal. Nature216, 1350–1351 (1967a)
Perris, A.D., Whitfield, J.F.: Stimulation of mitosis in bone marrow and thymus of normal and irradiated rats by divalent cations and parathyroid extract. Radiat. Res.32, 550–563 (1967b)
Perris, A.D., MacManus, J.P., Whitfield, J.F., Weiss, L.A.: Parathyroid glands and mitotic stimulation in rat bone marrow after hemorrhage. Amer. J. Physiol.220, 773–778 (1971)
Perris, A.D., Morgan, J.I.: The interaction of divalent cations, hormones and cyclic nucleotides in the control of mitosis. Calcif. Tiss. Res. (Suppl.)21, 15–20 (1976)
Radden, B.C., Fulmer, H.M.: Morphological and histochemical studies of bone repair in the rat. Arch. oral Biol.14, 1243–1252 (1969)
Rixon, R.H., Whitfield, J.F., Bayliss, J.: The stimulation of mitotic activity in the thymus and bone marrow of rats by kallikrein. Horm. Metab. Res.3, 279–284 (1971)
Tatevossian, A.: Effect of parathyroix extract on blood calcium and osteoclast count in mice. Calcif. Tiss. Res.11, 251–257 (1973)
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Johnell, O., Hulth, A. Proliferation of osteoclasts in rat bone following bleeding and femoral fractures. Calc. Tis Res. 23, 241–244 (1977). https://doi.org/10.1007/BF02012792
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DOI: https://doi.org/10.1007/BF02012792