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Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects

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Summary

SMS 201 995 is a new long acting analogue of somatostatin. We have investigated its effect on basal and meal stimulated secretion of gut hormones and have shown that after a single s. c. injection of 50 μg it lowers significantly the basal plasma levels of pancreatic polypeptide, secretin, motilin, pancreatic glucagon and insulin, it also effectively suppresses the postprandial release of pancreatic polypeptide, gastrin, secretin, gastric inhibitory peptide, pancreatic glucagon and insulin. Except for the usual brief discomfort of an injection, no symptoms or untoward effects were observed.

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References

  1. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., and Guillemin, R., Science179 (1973) 77.

    Article  CAS  PubMed  Google Scholar 

  2. Schusdziarra, V., Horm. Metab. Res.12 (1980) 563.

    Article  CAS  PubMed  Google Scholar 

  3. Siler, T. M., Yen, S. S. C., Vale, W., and Guillemin, R., Clin. Endocr.38 (1974) 742.

    Article  CAS  Google Scholar 

  4. Bloom, S. R., Motimer, C. H., Thorner, M. O., Besser, G. M., Hall, R., Gomez-Pan, A., Roy, V. M., Russel, R. C. G., Coy, D. H., Kastin, A. J., and Schally, A., Lancet1 (1974) 1106.

    Article  Google Scholar 

  5. Rivier, J., Brown, M., and Vale, W., Biochem. biophys. Res. Commun.65 (1975) 746.

    Article  CAS  PubMed  Google Scholar 

  6. Brown, M., Rivier, J., and Vale, W., Science196 (1977) 1467.

    Article  CAS  PubMed  Google Scholar 

  7. Vale, W., Rivier, J., Ling, N., and Brown, N., Metabolism27, suppl. 1 (1978) 1391.

    Article  CAS  PubMed  Google Scholar 

  8. Bauer, W., Briner, U., Doeptner, W., Haller, R., Huguenin, R., Marbach, P., Petcher, T. J., and Pless, J., Life Sci.31 (1982) 1133.

    Article  CAS  PubMed  Google Scholar 

  9. Bloom, S. R., and Long, R. G., Radioimmunoassay of gut regulatory peptides. W. B. Saunders Co. Ltd., London 1982.

    Google Scholar 

  10. Sheppard, M., Shapiro, B., Primstone, B., Kronheim, S., Berelowitz, M., and Gregory, M., J. clin. Endocr. Metab.43 (1979) 50.

    Article  Google Scholar 

  11. Vale, W., Rivier, C., Brazeau, P., and Guillemin, R., Endocrinology95 (1974) 968.

    Article  CAS  PubMed  Google Scholar 

  12. Redding, T. W., and Coy, D. H., 56th Meeting of the American Endocrine Society, Atlanta, 1984 (Abstract 198).

  13. Long, R. G., Peters, J. R., Bloom, S. R., Brown, M. R., Vale, W., Rivier, J. E., and Grahame-Smith, D. G., Gut22 (1981) 549.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Long, R. G., Peters, J. R., Bloom, S. R., Brown, M. R., Rivier, J. E., Barnes, A. J., Mallinson, C. N., Vale, W., and Christofides, N. D., Lancet2 (1979) 764.

    Article  CAS  PubMed  Google Scholar 

  15. Adrian, T. E., Barnes, A. J., Long, R. G., O'Shaughnessy, D. J., Brown, M., Rivier, J., Vale, W., Blackburn, A. M., and Bloom, S. R., J. clin. Endocr. Metab.53 (1981) 675.

    Article  CAS  PubMed  Google Scholar 

  16. Frolich, J. C., Bloomgarden, Z. T., Oates, J. A., McGuigon, J.E., and Rabinowitz, D., N. Engl. J. Med.299 (1978) 1055.

    Article  CAS  PubMed  Google Scholar 

  17. Wood, S. M., Kraenzlin, M. E., and Bloom, S. R., Gut, in press (1985).

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Authors and Affiliations

  1. Department of Medicine, Hammersmith Hospital, London, England

    M. E. Kraenzlin, S. M. Wood, M. Neufeld, T. E. Adrian & S. R. Bloom

  2. Clinical Research Division, Experimental Therapeutics Department, Sandoz Ltd, CH-4002, Basel, Switzerland

    M. E. Kraenzlin, S. M. Wood, M. Neufeld, T. E. Adrian & S. R. Bloom

Authors
  1. M. E. Kraenzlin
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  2. S. M. Wood
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  3. M. Neufeld
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  4. T. E. Adrian
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  5. S. R. Bloom
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Kraenzlin, M.E., Wood, S.M., Neufeld, M. et al. Effect of long acting somatostatin-analogue, SMS 201995, on gut hormone secretion in normal subjects. Experientia 41, 738–740 (1985). https://doi.org/10.1007/BF02012573

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  • DOI: https://doi.org/10.1007/BF02012573

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