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Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

Tingenone and horminone, two natural quinonoid substances, inhibited the in vitro growth ofTrypanosoma cruzi, 30 μM drug concentration producing total inhibition of growth. Tingenone inhibited total uptake and incorporation of [3H]thymidine, [3H]uridine, L-[3H]leucine into parasite macromolecules. Other quinonoids assayed were either less effective (abruquinone A) or even quite inactive (visminone B and ferruginin B). Investigation of several mechanisms for the cytotoxic action of tingenone pointed to the interaction with DNA as the most likely factor involved. Tingenone also inhibited the growth ofCrithidia fasciculata, but the drug was significantly less active on this organism than onT. cruzi.

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Authors and Affiliations

  1. Centro de Investigaciones Bionergéticas, Facultad de Medicina, Universidad de Buenas Aires, Paraguay 2155, 1121, Buenos Aires, Argentina

    S. G. Goijman, J. F. Turrens & A. O. M. Stoppani

  2. Centro Chimica dei Ricettori del C.N.R., Instituto di Chimica, Universitá Cattolica del S. Cuore, Roma, Italy

    G. B. Marini-Bettolo

Authors
  1. S. G. Goijman
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  2. J. F. Turrens
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  3. G. B. Marini-Bettolo
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  4. A. O. M. Stoppani
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Additional information

This work was supported by grants of UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases, Organization of American States (Multinational Programme of Biochemistry) and Programa Nacional de Enfermedades Endémicas (SECYT), República Argentina. A preliminary account was given at the Workshop on Oxidative Damage and Related Enzymes, Frascatti (Italy), 1983.

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Goijman, S.G., Turrens, J.F., Marini-Bettolo, G.B. et al. Effect of tingenone, a quinonoid triterpene, on growth and macromolecule biosynthesis in Trypanosoma cruzi. Experientia 41, 646–648 (1985). https://doi.org/10.1007/BF02007701

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  • DOI: https://doi.org/10.1007/BF02007701

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