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Contribution of each ventricular wall to ventricular interdependence

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Summary

The influences of presure and volume changes in one ventricle on the other ventricle may be determined from the relative compliances of the ventricular free walls and the interventricular septum. If this is correct, then disease states which alter regional compliances should influence the diastolic mechanical coupling between the ventricles. To examine this hypothesis, the hearts of 15 canine dogs were removed and placed in cool cardioplegic solution. Balloons were inserted into each ventricle and the right and left ventricular pressure (ΔPr, ΔPl) and volume (ΔVr, ΔVl) changes caused by changing the pressure and volume of the other ventricle were recorded. Acute changes in right ventricular free wall (N=5), septal (N=5), and left ventricular free wall (N=5) compliances were induced by glutaraldehyde injections. After injecting glutaraldehyde into the right coronary artery, ΔPl/ΔVr, ΔVl/ΔVr, ΔPr/ΔPl, and ΔPr/ΔVl increased significantly (P<0.05). After septal artery injection, pressure and volume transfer between the ventricles was significantly depressed. After left coronary artery injection, ΔPl/ΔPr, ΔPl/ΔVr, ΔPr/ΔVl, and ΔVr/ΔVl increased significantly (P<0.05). Thus, selective alterations in the mechanical coupling between the ventricles occurred following changes in right ventricular, septal, and left ventricular free wall compliances. Such changes may be important in diseases which primarily affect one side of the heart.

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Author notes

  1. W. P. Santamore Ph.D.

    Present address: Section of Cardiology, Bowman Gray School of Medicine, Wake Forest University, 300 South Hawthorne Road, 27103, Winston-Salem, North Carolina, USA

Authors and Affiliations

  1. Section of Cardiology, Bowman Gray School of Medicine, Wake Forest University, 300 South Hawthorne Road, 27103, Winston-Salem, North Carolina, USA

    M. Constantinescu, B. M. Minczak, C. E. Hock & L. Papa

  2. Cardiology Section, University of Medicine & Dentistry of New Jersey, School of Osteopathic Medicine, Camden, New Jersey, USA

    W. P. Santamore Ph.D., M. Constantinescu, B. M. Minczak, C. E. Hock & L. Papa

Authors
  1. W. P. Santamore Ph.D.
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  2. M. Constantinescu
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  3. B. M. Minczak
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  4. C. E. Hock
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  5. L. Papa
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Additional information

This study was supported in part by NIH Grant No. HL 36068 by a grant from the American Heart Association, New Jersey Chapter.

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Santamore, W.P., Constantinescu, M., Minczak, B.M. et al. Contribution of each ventricular wall to ventricular interdependence. Basic Res Cardiol 83, 424–430 (1988). https://doi.org/10.1007/BF02005828

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  • DOI: https://doi.org/10.1007/BF02005828

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