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In vitro effect of cetirizine on PGE2 release by rat peritoneal macrophages and human monocytes

  • Allergy and Histamine
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Abstract

Cetirizine was first described as a specific anti-H1 molecule displaying potent antiallergic activity. It was later found that its pharmacological properties extended to cellular actions as on eosinophil recruitment at inflammatory sites in allergic patients. Monocytes and macrophages participate in allergic mechanisms, particularly through high affinity H1 and H2 membrane receptors and generation of pro- and anti-inflammatory agents; among them histamine-induced factors, IL-1 and prostanoids are of importance. The aim of this work was to investigate the effect exerted by various concentrations of cetirizine (0.1–10 μg/ml) appliedin vitro to human monocytes and peritoneal rat macrophages cultured for 24 h. Peritoneal macrophages were collected either from normal or experimentally inflamed rats. Human monocytes, isolated from peripheral blood, were studied either in a resting state or after stimulation by LPS fromEscherichia coli (1 and 10 μg/ml). Cetirizine (10 μg/ml) significantly enhanced IL-1 release by human monocytes stimulated by a weak LPS concentration (1 μg/ml) but could not modify the maximal increase of IL-1 release induced by 10 μg/ml of LPS. It did not exert any effect on resting cells. Cetirizine (0.1–10 μg/ml) enhanced PGE2 release by resting human monocytes. Concentrations of 1 and 10 μg/ml enhanced PGE2 release by LPS-stimulated monocytes, and by healthy and inflamed rat macrophages. This effect was concentration-dependent. Our findings point to an anti-inflammatory action of cetirizine via PGE2 release and histamine H2 interactions. Cetirizine did not directly modify IL-1 generation by resting monocytes but the IL-1 production observed after LPS stimulation could promote the mechanisms by which PGE2 is released.

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References

  1. C. De Vos, M. R. Maleux and J. Gobert,Anti-allergic properties of cetirizine 2HCl in various models of anaphylaxis in animals, Allergologia Immunologia Clinica2, abst. 18 (1987).

    Google Scholar 

  2. L. Juhlin, C. De Vos and J. P. RihouxInhibiting effect of cetirizine on histamine-induced and 48/80-induced wheals and flares, experimental dermographism, and cold-induced urticaria. J. Allergy Clin. Immunol.80, 599–604 (1987).

    Article  PubMed  Google Scholar 

  3. J. P. Rihoux and P. Dupont,Comparative study of the peripheral and central effects of terfenadine and cetirizine 2 HCl. Ann. Allergy59, 235–239 (1987).

    PubMed  Google Scholar 

  4. R. Fadel, N. Herpin-Richard, J. P. Rihoux and E. Henocq,Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo. Clin. Allergy17, 373–379 (1987).

    PubMed  Google Scholar 

  5. L. Michel, C. De Vos, J. P. Rihoux and L. Dubertret,Inhibitory effect of cetirizine on allergen induced histamine and PGD2 release and on eosinophil recruitment in allergic patients. Allerg. Immunol. Clin.2, 82 (1987).

    Google Scholar 

  6. C. Leprevost, M. Capron, C. De Vos M. Tomassini and A. Capron,Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). Int. Arch. Allergy Appl. Immunol.87, 9–13 (1988).

    PubMed  Google Scholar 

  7. G.M. Walsh, R. Moqbel, A. Hartnell and A. B. Kay,Effects of cetirizine on human eosinophil and neutrophil activation, Int. Arch. Allergy Appl. Immunol.95, 158–162 (1991).

    PubMed  Google Scholar 

  8. T. P. Atkinson, M. V. White and M. A. Kaliner,Histamine and serotonin. InInflammation, Basic Principles and Clinical Correlates, 2nd Edition. (Eds. J. I. Gallin, I. M. Goldstein and R. Snyderman) pp. 193–209, Raven Press, New York 1992.

    Google Scholar 

  9. T. B. Bury, J. L. Corhay and M. F. Radermecker,Histamine-induced inhibition of neutrophil chemotaxis and T-lymphocyte proliferation in man. Allergy47, 624–629 (1992).

    PubMed  Google Scholar 

  10. L. Steel, L. Platshon and M. Kaliner,Prostaglandin generation by human and guinea pig lung tissue: Comparison of parenchymal and airway responses. J. Allergy Clin. Immunol.64, 287–293 (1979).

    PubMed  Google Scholar 

  11. O. F. Cole and G. P. Lewis,Prostanoid production by rat aortic endothelial cells by bradykinin and histamine. Eur. J. Pharmacol.169, 307–312 (1989).

    Article  PubMed  Google Scholar 

  12. M. E. Goldyne and J. D. Stobo,Immunoregulatory role of prostaglandins and related lipids, Crit. Rev. Immunol.2, 189–223 (1981).

    Google Scholar 

  13. I. M. Goldstein,Agents that interfere with arachidonic acid metabolism. InInflammation, Basic Principles and Clinical Correlates, 2nd Edition. (Eds. J. I. Gallin, I. M. Goldstein and R. Snyderman) pp. 1127–1137, Raven Press, New York 1992.

    Google Scholar 

  14. E. J. Schulman, R. C. Liu, D. Proud, D. W. Mac Glashau, L. Lichtenstein and M. Plaut,Human lung macrophages induce histamine release from basophils and mast cells, Am. Rev. Resp. Dis.131, 230–235 (1985).

    PubMed  Google Scholar 

  15. R. Alam, P. A. Forsythe, M. A. Lett-Brown and J. A. Grant,Cellular origin of histamine releasing factor produced by peripheral blood mononuclear cells, J. Immunol.142, 3951–3955 (1989).

    PubMed  Google Scholar 

  16. D. J. Beer, C. A. Dinarello, L. J. Rosenwasser and R. E. Rocklin,Human monocyte-derived soluble product(s) has an accessory function in the generation of histamine- and concanavalin A-induced suppressor T cell factor, J. Clin. Invest.70, 393–400 (1982).

    PubMed  Google Scholar 

  17. R. E. Rocklin, I. Kiselis, D. J. Berr, P. Rossi, F. Maggi and J. A. Bellanti,Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). Cell Immunol.77, 92–98 (1983).

    Article  PubMed  Google Scholar 

  18. M. Roch-Arveiller, R. Legros, B. Chanaud, O. Muntaner, S. Stzalko, A. Thuret, D. A. Willoughby and J. P. Giroud,Inflammatory reactions induced by various calcium pyrophosphate crystals, Biomed. Pharmacother.44, 467–474 (1990).

    Article  PubMed  Google Scholar 

  19. M. Tissot, S. Strzalko, A. Thuret and J. P. Giroud,Prostanoid release by macrophages at a distance from an inflammatory site. Brit. J. Exp. Path.70, 525–531 (1989).

    PubMed  Google Scholar 

  20. S. B. Tucker, R. V. Pierre and R. F. Jordon,Rapid identification of monocytes in a mixed mononuclear cell preparation, J. Immunol Methods14, 217–219 (1977).

    Article  Google Scholar 

  21. J. S. Goodwin and D. R. Webb,Regulation of the immune response by prostaglandins, Clin. Immunol. Immunopath.15, 106–122 (1980).

    Article  Google Scholar 

  22. R. P. Phipps, S. H. Stein and R. L. Roper,A new view of prostaglandin E regulation of the immune response. Immunology Today12, 349–352 (1991).

    Article  PubMed  Google Scholar 

  23. P. Davies and D. E. McIntyre,Prostaglandins and inflammation. InInflammation, Basic Principles and Clinical Correlates, 2nd Edition. (Eds. J. I. Gallin, I. M. Goldstein and R. Snyderman) pp. 123–138, Raven Press, New York 1992.

    Google Scholar 

  24. S. L. Kunkel, L. H. Oggawa, P. G. Conran, P. A. Ward and R. B. Zurier,Suppression of acute and chronic inflammation by orally administered prostaglandins. Arth. Rheum.13, 1151–1158 (1981).

    Google Scholar 

  25. J. S. Goodwin,Are prostaglandins pro inflammatory, anti inflammatory, both or neither? J. Rheumatol.18 (Suppl. 28), 26–29 (1991).

    Google Scholar 

  26. J. C. Fantone, S. L. Kunkel, P. A. Ward and R. B. Zurier,Suppression by prostaglandin E, of vascular permeability induced by vasoactive inflammatory mediators, J. Immunol.125, 2591–2596 (1980).

    PubMed  Google Scholar 

  27. S. Chouaib, R. J. Robb, K. Welte and B. Dupont,Analysis of prostaglandin E 2 effect on T lymphocyte activation, J. Clin. Invest.80, 333–340 (1987).

    PubMed  Google Scholar 

  28. R. E. Rocklin,Histamine and H2 Antagonists in Inflammation and Immunodeficiency, Marcel Dekker, Ed New York 1990.

    Google Scholar 

  29. A. Falus and K. Merétey,Histamine: an early messenger in inflammatory and immune reactions, Immunology Today13, 154–156 (1992).

    Article  PubMed  Google Scholar 

  30. L. Michel, C. De Vos, J. P. Rihoux, C. Burtin, J. Benveniste and L. Dubertret,Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and Paf-acether release and eosinophil recruitment in human skin. J. Allergy Clin. Immunol.82, 101–109 (1988).

    PubMed  Google Scholar 

  31. L. Michel, C. De Vos and L. Dubertret,Cetirizine effects on the cutaneous allergic reaction in humans, Ann. Allergy65, 512–516 (1990).

    PubMed  Google Scholar 

  32. D. E. Van Epps, S. G. Kurvit and J. W. Potter,In vitro effects of cetirizine and histamine on human neutrophil function. Ann. Allergy59, 13–19 (1987).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Département de Pharmacologie, Pavillon Gustave Roussy, CNRS URA 1534, 27 rue du Faubourg St. Jacques, F-75679, Paris Cedex 14, France

    M. Roch-Arveiller, M. Tissot, N. Idohou & J. P. Giroud

  2. Biochimie A2, Hôpital Cochin, 27 rue du Faubourg St. Jacques, F-75679, Paris Cedex 14, France

    N. Idohou, G. Sarfati & D. Raichvarg

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  1. M. Roch-Arveiller
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  2. M. Tissot
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  3. N. Idohou
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  4. G. Sarfati
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  5. J. P. Giroud
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  6. D. Raichvarg
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Roch-Arveiller, M., Tissot, M., Idohou, N. et al. In vitro effect of cetirizine on PGE2 release by rat peritoneal macrophages and human monocytes. Agents and Actions 43, 13–16 (1994). https://doi.org/10.1007/BF02005756

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  • DOI: https://doi.org/10.1007/BF02005756

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