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Opposite effects ofβ-adrenoceptor stimulation and 8-bromo-cyclic AMP on potassium efflux in mammalian heart muscle

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Summary

β-adrenoceptor stimulation by isoprenaline increases the potassium efflux in beating guinea-pig atria. This effect is not mimicked by 8-bromo-cyclic AMP, a cyclic AMP analogue which exerts a positive inotropic effect in this preparation.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Mainz, D-6500, Mainz, Germany

    H. Nawrath, I. Blei & R. Gegner

Authors
  1. H. Nawrath
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  2. I. Blei
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  3. R. Gegner
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Nawrath, H., Blei, I. & Gegner, R. Opposite effects ofβ-adrenoceptor stimulation and 8-bromo-cyclic AMP on potassium efflux in mammalian heart muscle. Experientia 36, 72–74 (1980). https://doi.org/10.1007/BF02003981

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