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Effect of substance P on the membrane potential of coronary arterial endothelial cellsin situ

  • Inflammation and Immunomodulation
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Abstract

The membrane potential of the endothelial cells on a strip of pig coronary artery was recorded. The fluorescent dye lucifer yellow was injected into the recorded cell in order to prove its identity. We show that substance P transiently hyperpolarized these cells. The function of the endothelial cell hyperpolarization could be important for the role played by the endothelium and the kinins in inflammation.

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Authors and Affiliations

  1. Départment de Zoologie et Biologie Animale, Université de Genève, 30, quai Ernest Ansermet, Science III, 1211, Genéve 4, Switzerland

    J. -L. Bény

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  1. J. -L. Bény
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Bény, J.L. Effect of substance P on the membrane potential of coronary arterial endothelial cellsin situ . Agents and Actions 31, 317–320 (1990). https://doi.org/10.1007/BF01997626

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  • DOI: https://doi.org/10.1007/BF01997626

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