Abstract
The effects of whole spores from moulds were examined concerning histamine release using leukocyte suspensions from normal (non-atopic) individuals and grass pollen-allergic patients. Spores fromChaetomium globosum, Mucor racemosus andAspergillus terreus caused no histamine release in concentrations up to 0.1 or 1 mg/ml, but they enhanced mediator release triggered by both IgE-dependent stimuli (grass-pollen allergen and anti-IgE antibody) and non-immunological stimuli (Staphylococcus aureus and calcium ionophore). Organic dust contains microfungi as well as bacteria and endotoxins. Earlier we have shown that bacteria release mediators from human lung cells and that bacteria and their endotoxins potentiate mediator release. It is now demonstrated that fungal spores also have potentiating ability. The content of all these microorganisms in dust may therefore be responsible for the symptoms observed after occupational exposure to organic dusts.
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References
R. Lecours, M. Laviolette and Y. Cormier,Bronchoalveolar lavage in pulmonary mycotoxicosis (organic dust toxic syndrome). Thorax41, 924–926 (1986).
P. Malmberg,Health effects of orgainic dust exposure in dairy farmers. Amer. J. Ind. Med.17, 7–15 (1990).
S. Norn,Microorganisms and mediator release: New aspects in airway diseases. InContribution to Autacoid Pharmacology. Agents and Actions, Suppl. vol36. (Ed. A. M. Rothschild) pp 57–77, Birkhäuser, Basel, 1992.
P. Stahl Skov and S. Norn,A simplified method for measuring basophil histamine release and blocking antibodies in hay fever patients. Basophil histamine content and cell preservation. Acta allerg.32, 170–182 (1977).
P. Stahl Skov, H. Permin and H.-J. Malling,Quantitative and qualitative estimation of IgE bound to basophil leukocytes from hay fever patients. Scand. J. Immun.6, 1021–1028 (1977).
K. Karlsson and P. Malmberg,Characterization of exposure to molds and actinomycetes in agricultural dusts by scanning electron microscopy, fluorescence microscopy and the culture method. Scand. J. Work Environ Health15, 353–359 1989).
P. Malmberg, A. Rask-Andersen, M. Lundholm and U. Palmgren,Can spores from molds and actionomycetes cause an organic dust toxis syndrome reactions? Amer. J. Ind. Med.17, 109–110 (1990).
R. Rylander,The role of endotoxin for reactions after exposure to cotton dust. Amer. J. Ind. Med.12, 687–697 (1987).
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Norn, S., Kristensen, K.S., Dien, T. et al. Fungal spores enhance basophil histamine release. Agents and Actions 38, C221–C223 (1993). https://doi.org/10.1007/BF01996466
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DOI: https://doi.org/10.1007/BF01996466