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Dosage of nifedipine in hypertensive crises of infants and children

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Abstract

Eight hypertensive crises (HC) were treated with 2.5 mg of sublingual nifedipine in three children with weights below 10 kg (group A); 16 HC in 6 children between 10 and 20kg with 5 mg (group B); and 40 HC in 10 children over 20kg with 10 mg of nifedipine (group C). The relative decrease in both systolic and diastolic blood pressure was similar in all groups. The decrease was more rapid in groups A and B when the contents were extracted from the capsule and given directly. The hypotensive effect lasted 4h. There were no side effects. The effective and safe single dose of nifedipine has been established to be 2.5 mg for children weighing less than 10 kg, and 5 mg for children weighing between 10 and 20 kg.

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Abbreviations

HC:

hypertensive crises

mDBP:

mean diastolic blood pressure

mSBP:

mean systolic blood pressure

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Authors and Affiliations

  1. Paediatric Intensive Care Unit, Children's Hospital “La Paz”, Puentecesures 1B-1°B, E-28029, Madrid, Spain

    J. Lopez-Herce, P. Dorao, P. de la Oliva, M. A. Delgado, M. C. Martinez & F. Ruza

Authors
  1. J. Lopez-Herce
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  2. P. Dorao
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  3. P. de la Oliva
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  4. M. A. Delgado
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  5. M. C. Martinez
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  6. F. Ruza
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Lopez-Herce, J., Dorao, P., de la Oliva, P. et al. Dosage of nifedipine in hypertensive crises of infants and children. Eur J Pediatr 149, 136–137 (1989). https://doi.org/10.1007/BF01995865

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  • DOI: https://doi.org/10.1007/BF01995865

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