Abstract
The local Shwartzman response was produced in rabbits by the intradermal injection of endotoxin, followed 24 h later by intravenous zymosan. Hemorrhagic lesions developed in the prepared skin sites. We quantitated the Shwartzman-induced hemorrhage with autologous99mTc-erythrocytes. We show that the development of the Shwartzman response depends on both leukocyte membrane CD18 glycoprotein activity as well as the participation of intercellular adhesion molecule-1 (ICAM-1). We discuss the possibility that the common property shared by the agents capable of preparing the skin for the Shwartzman response in the ability to induce ICAM-1 expression.
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Argenbright, L.W., Barton, R.W. The Shwartzman response: A model of ICAM-1 dependent vasculitis. Agents and Actions 34, 208–210 (1991). https://doi.org/10.1007/BF01993281
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DOI: https://doi.org/10.1007/BF01993281