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Properties of tuberomammillary histamine neurones and their response to galanin

  • Histamine and the Nervous System
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Abstract

Histaminergic neurones in the tuberomammillary nucleus possess electrophysiological properties which distinguish them from other neurones in their neighborhood. Their resting potential is −50 mV and they are spontaneously active at about 2 Hz in a slice preparation. They display a transient outward rectification and an anomalous inward rectification. Bath application of galanin (0.1 μM) reduced their firing rate significantly and hyperpolarized them slightly.

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References

  1. J. C. Schwartz, M. Garbarg and H. Pollard,Histaminergic transmission in the brain. InHandbook of physiology, the nervous system, Vol. IV (Ed. F. E. Bloom, V. B. Mountcastle and S. R. Geiger) pp. 257–316. American Physiological Society, Bethesda 1988.

    Google Scholar 

  2. H. L. Haas and P. B. Reiner,Membrane properties of histaminergic tuberomammillary neurones of the rat hypothalamus in vitro. J. Physiol.399, 633–646 (1988).

    PubMed  Google Scholar 

  3. R. W. Greene, H. L. Haas and P. B. Reiner,Two transient outward currents in histamine neurones of the rat hypothalamus in vitro. J. Physiol.420, 149–163 (1990).

    PubMed  Google Scholar 

  4. T. Nilsson, P. Arkhammar, P. Rorsman and P. O. Berggren,Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarisation and reduction in cytoplasmic free Calcium concentration. J. Biol. Chem.264, 973–980 (1989).

    PubMed  Google Scholar 

  5. A. Ottlecz, G. D. Snyder and S. M. McCann,Regulatory role of galanin in control of hypothalamic-anterior pituitary function. Proc. Natl. Acad. Sci. USA85, 9861–9865 (1988).

    PubMed  Google Scholar 

  6. J. I. König, S. Hooi, S. M. Gabriel and J. B. Martin,Potential involvement of galanin in the regulation of fluid homeostasis in the rat. Regul. Pept.24, 81–86 (1989).

    PubMed  Google Scholar 

  7. C. Köhler, H. Ericson, T. Watanabe, J. Polak, S. L. Palay, V. Palay and V. Chan-Palay,Galanin immunoreactivity in hypothalamic histamine neurons: further evidence for multiple chemical messengers in the tuberomammillary nucleus. J. Comp. Neurol.250, 58–64 (1986).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Physiologie und Pathophysiologie, Johannes-Gutenberg Universität Mainz, Saarstraße 21, D-6500, Mainz

    B. Schönrock, D. Büsselberg & H. L. Haas

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  1. B. Schönrock
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  2. D. Büsselberg
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  3. H. L. Haas
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Schönrock, B., Büsselberg, D. & Haas, H.L. Properties of tuberomammillary histamine neurones and their response to galanin. Agents and Actions 33, 135–137 (1991). https://doi.org/10.1007/BF01993148

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  • DOI: https://doi.org/10.1007/BF01993148

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