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Podolide, a new antileukemic norditerpene dilactone fromPodocarpus gracilior

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Zusammenfassung

Nachweis, dass Podolid, ein neues antileukämisches norditerpinisches Dilacton ausPodocarpus gracilior Pilg. die Struktur (1) besitzt.

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References

  1. For a recent review seeM. N. Galbraith, D. H. S. Horn, S. Itô, M. Kodama andJ. M. Sasse, Agric. Biol. Chem36 2393 (1972).

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  2. Tumor-inhibitory activity and cytotoxicity were assayed under the auspices of the National Cancer Institute, by the procedures described byR. I. Geran, N. H. Greenberg, M. M. McDonald, A. M. Schumacher andB. J. Abbott (Cancer Chemother. Rep. part 3,3, 1 (1972)). Podolide showed significant activity in vivo against P-388 leukemia in mice and cytotoxicity in vitro towards cells derived from both human carcinoma of the nasopharynx (KB) and P-388 murine leukemia.

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  3. Podolide was accompanied by trace amounts of its 2,3-dihydro derivative which could be removed by fractional crystallization from methanol.

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Authors and Affiliations

  1. Department of Chemistry, University of Virgina, 22901, Charlottesville, Virgina, USA

    S. M. Kupchan, R. L. Baxter, Myra F. Ziegler, P. M. Smith & R. F. Bryan

Authors
  1. S. M. Kupchan
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  2. R. L. Baxter
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  3. Myra F. Ziegler
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  4. P. M. Smith
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  5. R. F. Bryan
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Additional information

Tumor Inhibitors. 99. For previous paper in the series, seeS. M. Kupchan, Recent Adv. Phytochem., in press.

We thank Dr.R. E. Perdue, jr., U.S.D.A., for supplying the plant material (collected in Ethiopia in November, 1964). The work was supported by grants from the National Cancer Institute (CA-11718 and CA-11760) and the American Cancer Society (CI-102J), and a contract with the Division of Cancer Treatment, National Cancer Institute (NO1-CM-12099).

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Kupchan, S.M., Baxter, R.L., Ziegler, M.F. et al. Podolide, a new antileukemic norditerpene dilactone fromPodocarpus gracilior. Experientia 31, 137–138 (1975). https://doi.org/10.1007/BF01990665

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