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Host defense against infections and inflammations: Role of the multifunctional IL-6/IFN-β2 cytokine

  • Multi-author Review
  • Recent Developments in Interferon Research
  • Published:
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Summary

IL-6/IFN-β2 appears to be one of the important mediators of the response to viral and bacterial infections and to shock. The biological effects now associated with IL-6/IFN-β2 include: stimulation of immunoglobulin secretion by mature B lymphocytes (BSF-2 activity), growth stimulation of plasmacytomas and hybridomas (HGF activity), activation of T cells, stimulation of hepatic acute phase protein synthesis (HSF activity), stimulation of hematopoiesis, cell differentiation (DIF activity), inhibition of tumor cell growth (AP activity) and other IFN-like effects. As a typical cytokine, IL-6/IFN-β2 is secreted by many cell types and acts in various combinations with other interleukins and interferons.

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  1. Department of Virology, Weizmann Institute of Science, 76 100, Rehovot, Israel

    M. Revel

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Revel, M. Host defense against infections and inflammations: Role of the multifunctional IL-6/IFN-β2 cytokine. Experientia 45, 549–557 (1989). https://doi.org/10.1007/BF01990505

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