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Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells afterin vitro activation by monooxygenase

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Abstract

The incubation of paracetamol with isolated rat serosal mast cells evokes the release of histamine only in the presence of (S10) liver microsomes obtained from PCB or phenobarbital treated rats. The release of histamine was not accompanied by a leakage of lactate dehydrogenase and was blocked by the antioxidant α-tocopherol and by D-mannitol, an hydroxyl free radicals scavenger. The data are consistent with the metabolic oxidation of paracetamol in the generation of reactive intermediates capable of activating the sequential exocytosis.

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Authors and Affiliations

  1. Department of Preclinical and Clinical Pharmacology ‘M. Aiazzi-Mancini’, University of Florence, Viale Morgagni 65, 50134, Firenze, Italy

    Emanuela Masini, Maura Lodovici, R. Fantozzi, Sandra Brunelleschi, A. Conti & P. F. Mannaioni

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  1. Emanuela Masini
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  2. Maura Lodovici
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  3. R. Fantozzi
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  4. Sandra Brunelleschi
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  5. A. Conti
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  6. P. F. Mannaioni
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Masini, E., Lodovici, M., Fantozzi, R. et al. Histamine release by free radicals: Paracetamol-induced histamine release from rat peritoneal mast cells afterin vitro activation by monooxygenase. Agents and Actions 18, 85–88 (1986). https://doi.org/10.1007/BF01987990

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  • DOI: https://doi.org/10.1007/BF01987990

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